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c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo on protein phosphorylation in the brain remain largely unknown. This study aimed to (1) determine how chronic JNK inhibition altered proteome-wide phosphorylation in hippocampus and nucleus accumbens, regions
Conversational agents are increasingly being introduced in healthcare to enhance access to healthcare and address limited healthcare resources. The aim of this study was to explore experiences of a conversational agent for symptom checking and triage tool assessing the urgency and appropriate level of care implemented in public healthcare from a cognitive accessibility perspective. With a Particip
Background: Early electrocardiograph predates electronic amplification and therefore required innovative and highly sensitive instrumentation. Willem Einthoven's introduction of the string galvanometer in 1903 enabled recording of clinically useful electrocardiograms and established electrocardiography as a diagnostic method. Objectives: To describe the provenance and technical features of a uniqu
Determining the drivers of intraspecific variation in cognitive performance is crucial for understanding how cognition evolves, but experimental studies are scarce. Several correlational studies have supported the hypothesis that living in larger groups enhances cognitive performance. However, empirical explanations of whether and how living in large groups causally affects individual cognitive pe
Rational & Objective: Sarcopenia is linked to increased morbidity and mortality in chronic kidney disease (CKD), but its definition and assessment vary considerably across studies. This study evaluated the technical feasibility of magnetic resonance imaging (MRI)–based assessment of adverse muscle composition (AMC)—defined as low muscle volume and high fat infiltration—and its associations wit
Many insects have a behavioral need for the rapid detection of small moving visual targets. In dragonflies and flies, Small Target Motion Detector (STMD) neurons have been found to fill this function, but observations in Hymenopterans raise questions of whether similar neurons are present. In high order variants of these neurons, predictive response gain modulation thought to be driven by dendriti
Kan flexibilitet i hushålls energisystem underlätta energiomställningen genom att dra nytta av volatila elpriser? Analysen av vår fallstudie visar att flexibla teknologier och framför allt värmeproduktion från el kan minska fossila utsläpp och driftkostnader, men ökar elanvändningen från nätet. Priserna på el har diskuterats frekvent de senaste åren och kraftiga prissvängningar har negativt påveThe increasing share of weather-dependent renewable energy in the European electricity system, as a consequence of the European Union’s climate ambitions, has led to increased spot price volatility, negatively affecting consumers due to unpredictability. This case study assesses how flexibility (including power-heat cross vector flexibility) in residential buildings can affect annual costs, emissi
Accurate, high-resolution global land use and land cover (LULC) mapping is crucial for environmental monitoring, but remains challenging when relying solely on multispectral data. Most existing global LULC mapping studies rely exclusively on multispectral observations, and even those that incorporate synthetic aperture radar (SAR) data often fail to fully exploit the information it provides. SAR p
Urbanization is driving cities to grow, often through urban densification. Utilising computer-based simulations executed over 3D representations of the city is imperative in addressing the challenges posed by implementing sustainable urban densifications; like ensuring adequate access to daylight and limiting noise pollution. However, since these simulations are usually resource-intensive, timecon
Background and importance: The major risk factor for vermilion lip squamous cell carcinoma (vlSCC) is excessive sunlight exposure. Population-based studies on treatment and outcome are lacking. Methods: This is a nation-wide, population-based study of treatment and outcome from prospectively recorded data for 2,111 vlSCC registered in the Swedish Head and Neck Cancer Register (SweHNCR) diagnosed 2
Epilepsy affects more than 50 million individuals worldwide, and approximately one-third of patients remain refractory to existing antiseizure medications. Advances in gene therapy and genome editing have opened new possibilities for disease-modifying interventions that directly target the molecular and circuit-level mechanisms underlying epileptogenesis. Recent progress in central nervous system
Access to detailed network data is often constrained by access-controlled datasets or by extensive manual labour. Using aerial imagery and a simplified OpenStreetMap road-level graph, a novel approach is proposed to extract lane-level road topology graphs at signalized intersections based on detection of common road objects, classification of lane attributes, and a simultaneous lane-to-lane connec
The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in l
The International Society for Heart and Lung Transplantation Consensus for Perioperative Utilization of Extracorporeal Life Support in Lung Transplantation consists of 111 Delphi-derived statements across 3 separate manuscripts. These statements aim to provide comprehensive phase-of-care recommendations for international multidisciplinary teams to use in their clinical practice from time of recipi
Integrating multi-modal patient data to support personalized medicine has gained a lot of interest across different health domains over the past decade. Addressing this challenge requires the development and implementation of an informed, evidence-based AI-driven decision-support system continuously maintained and updated to align with the latest clinical guidelines. A key challenge to ensure its
This qualitative study analyses exaggeration in natural conversation from a dialogic perspective using data from the London–Lund Corpus 2 (LLC–2). We define exaggeration as an extreme degree on a scale, e.g., my bag weighs a ton. degree is central to our definition of exaggeration, which involves scaling a gradable property up, or down, to a level that comes across as counterfactual or inappropria
