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PURPOSE: Early administration of beta-lactam antibiotics is a crucial part in the treatment of sepsis and septic shock. Beta-lactams demonstrate time-dependent killing and therefore it is important to optimize the time above the minimal inhibitory concentration (MIC). An extra dose is recommended in threatening/suspected/confirmed septic shock. This study aimed to examine whether patients with sus

BACKGROUND: Sepsis-induced coagulopathy (SIC) is a scoring system developed for early detection of coagulopathy in sepsis and selection of patients for interventional studies. Our aim was to define the prevalence of SIC in a critically ill population and investigate if SIC at intensive care unit (ICU) admission is associated with morbidity and mortality.METHODS: Patients admitted with septic shock

Boreal forests play a crucial role in the global carbon cycle and currently act as an important carbon sink. At the same time, these forests are increasingly affected by intensive forest management and a changing disturbance regime driven by climate change. Clear-cutting has been the dominant harvesting method in managed boreal forests, while wildfire, although rare over the last century in Sweden

Background: The presence of cancer in pelvic lymph nodes removed during radical surgery for muscle-invasive bladder cancer (MIBC) is a key determinant of patient outcome. It would be beneficial to predict node status preoperatively to tailor the use of neoadjuvant chemotherapy and extent of lymph node dissection. Of 12 published node status predictors based on tumor RNA expression signatures, non

Elevated endostatin levels independently predicted 3-month mortality in acute dyspnoeapatients with CHF, but not 1-month mortality. Endostatin may aid intermediate-term risk stratification and warrants further validation.

OBJECTIVES: This study aims to compare the performance on motor and cognitive functions of adult patients with attention deficit hyperactivity disorder (ADHD) with or without psychostimulant medication, and controls. A secondary objective is to investigate differences on test performance across varying levels of disorder severity.METHODS: We included patients with unmedicated ADHD (n=52), patients

Gal-3 appears clinically useful for ruling out short-term mortality in patients with acute dyspnea and could have role as a negative prognostic marker in the emergency department.

In addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence generaIn addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence genera

Detta examensarbete genomfördes i nära samarbete med Donya Tech AB, som utvecklar ett smart graviditetsband som följer fosterrörelser. Syftet med arbetet är att utveckla ett avtagbart elektronikhölje som ska integreras i plagget och skyddar den elektronik som används. Arbetet har utgått från Ulrich och Eppinger´s produktutvecklingsprocess i kombination med Rapid Prototyping, vilket möjliggjorde enThis master thesis project was carried out in close collaboration with Donya Tech AB, who are developing a smart pregnancy band that monitors fetal movements. The aim of the project is to develop a removable electronic housing that will be integrated into the garment and protect its components. The work has been based on Ulrich and Eppinger’s Product Development Process in a combination with Rapid

This thesis examines the practices and importance of the “care-tree” (vårdträd) for human-nature relations in Sweden during the 19th and early 20th centuries. The “care-tree” have a long history of use, are entwined with supernatural beliefs, and are said to reflect the well-being and luckiness of the yard where it’s planted. Using theories of social control, non-human agencies and the dwelling pe

Background: Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. Methods: We conducted GWA

Articular cartilage undergoes structural and compositional changes during osteoarthritis (OA), one of the most common joint diseases. Earlier research shows that these changes are dependent on species and joint site, and they also vary across cartilage depth. In this study, we analyzed the depth-wise proteoglycan and collagen contents, as well as collagen fibril orientation angle and fibril alignm