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PURPOSE:Among available tumour necrosis factor inhibitors (TNF-inhibitors) only etanercept is approved for treatment of children with polyarticular course juvenile arthritis. Nevertheless also infliximab and adalimumab are used in selected cases, especially in patients having failed on etanercept.The objective was to evaluate adherence to therapy (a combined measure of efficacy and side effects as
As artistic research grows into an established mode of academic inquiry, it has become possible to distinguish a ruling metaparadigm which we denote as the practice paradigm. This paradigm is to a large extent based on the argument that artistic research is not equipped to produce standalone theories, but instead offers ways to develop and disseminate knowledge through sensory media and embodiment
Studio recordings of music for English bass horn and string trio from the composers Louis Massonneau, Emma Jane Lloyd, and Ylva Lund Bergner, recorded at the St Cecilia's Hall in Edinburgh on 17 January 2026.
Designing composite photocatalytic systems with nanoscale precision is crucial. While conventional facet-selective photo-deposition successfully utilizes spherical co-catalysts, the directed deposition of pre-synthesized two-dimensional (2D) materials onto specific facets remains extremely challenging. This work demonstrates an electrostatic assembly strategy for the precise deposition of 2D trans
In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal antibodies—a deeper understanding of how inflammatory a
The lung may be the organ whose mechanical environment needs to be most finely tuned to achieve optimal function. These needs have to be fulfilled at multiple scales, from proper force transmission between the chest wall and the parenchyma to reduction of surface tension by surfactants inside the alveoli. In addition, a plethora of mechanical loads and forces takes place within the lung, from the
Mobile Stroke Units (MSUs), which are specialised ambulances equipped with brain imaging devices and trained medical personnel, offer the potential for rapid on-site diagnosis and treatment, improving patient outcomes in prehospital stroke care. To fully realise their benefits, it is essential to strategically allocate. However, identifying optimal locations within a region for MSU deployment is t
Begreppet landsbygd används ofta som om dess innebörd vore självklar. I statistik, politik och samhällsdebatt beskrivs landsbygden ofta som motsatsen till staden: gles, avlägsen och präglad av jordbruk och natur. Denna rapport visar dock att landsbygden inte är ett enkelt eller entydigt fenomen. Tvärtom är landsbygd – eller ruralitet – ett komplext, föränderligt och relationellt begrepp som formas
Hur vi tar oss fram i vardagen påverkar inte bara vår egen livskvalitet, utan också klimatet, ekonomin och hur våra samhällen utvecklas. I Skåne, där både storstadsområden och gles landsbygd samsas i samma region, är mobilitet en särskilt viktig fråga. Den här rapporten undersöker vad ett stort antal regionala dokument säger om framtidens transporter med fokus på landsbygden.Ett av de tydligaste r
När vi pratar om mobilitet tänker många på bussar, tåg och bilar. Men på landsbygden handlar mobilitet om något större: tillgång till livet. Dagens sätt att mäta transporter är utformat för städer och fokuserar på kostnad per passagerare och restid. Dessa mått fungerar dåligt i glesbygd, där avstånd inte är ett val utan en geografisk realitet. Människor kör bil ofta för att det helt enkelt saknas
In everyday listening, speech perception occurs under conditions where acoustic information may be incomplete or ambiguous, including background noise and variability in signal quality. Listeners must navigate ambiguous, masked or rapidly unfolding speech signal in order to comprehend spoken language. While prediction has been widely discussed and acknowledged in speech perception, less is known a
BACKGROUND: – The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populations meeting 2010 Task Force Criteria. However, the calculator includes no measure of left ventricular (LV) structure and function, while late gadolinium enhancement (LGE) on cardiac magnetic resonance shows p
Den här rapporten undersöker hur Sölvesborgs kommun kan stärka hållbar mobilitet och samtidigt använda centrala ytor mer effektivt genom att etablera mobilitetshubbar. En mobilitetshubb kan beskrivas som en samlad nod där flera färdmedel och tjänster möts: cykelparkering, laddning, bilpool, lånecyklar, information, bokning och möjligheter att byta mellan gång, cykel, buss och tåg. I stället för at
Understanding water interactions in complex systems is crucial, as they play a key role in fields such as biochemistry, pharmaceutical formulations, and food science. Nuclear magnetic resonance (NMR) relaxation measurements have become one of the widely used methods to visualize various water characteristics owing to their noninvasive nature and ease of use. However, unambiguous data interpretatio
Understanding the atomic-scale interfaces in advanced semiconductor heterostructures is essential for controlling defects, optimizing material properties, and ensuring device reliability. In this work, we present a comprehensive study of the atomic structure at Al(Ga)N interfaces in N-polar GaN high-electron-mobility transistor structures (HEMTs) via aberration-corrected annular dark field scannin
Cambodia’s opening of Techo International Airport and the consolidation of the Bakong digital payment system signal a shift towards a more state-led and financially sophisticated development model. These initiatives reflect the Cambodian state’s expanding role in planning, financing and governing large-scale infrastructure and digital systems, deepening direct participation in development. While d
Epithelial-to-mesenchymal transition (EMT), driven by cues from the tumor microenvironment, is a critical initiator of metastatic progression. In breast cancer patients, elevated expression of cartilage oligomeric matrix protein (COMP) is associated with shorter survival and increased metastatic risk. Here, we investigated the role of COMP in regulating EMT in breast cancer. Breast cancer cells tr
Introduction: Traumatic axonal injury (TAI), often caused by rapid rotational forces and high-energy accidents, is common in severe traumatic brain injury (sTBI). The intracranial pressure (ICP) dynamics are often unpredictable, and the need for ICP monitoring remains debated. Research question: What is the incidence of ICP elevation in patients with TAI, and how often is escalated ICP-lowering tr
