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Background: Diffuse large B-cell lymphoma (DLBCL) exhibits immunological heterogeneity that influences outcomes of immunochemotherapy, with CD8+ T cells playing a critical role in patient prognosis. Methods: We integrated single-cell and bulk transcriptome data to establish a CD8⁺ T cell–associated prognostic signature. Single-cell RNA sequencing data from 29 samples (28 individuals), including DL

Inflammation and infection remain unmet challenges in wounds of various etiologies, delaying healing, impacting quality of life, and increasing healthcare costs. The thrombin-derived C-terminal peptide TCP-25 has demonstrated dual anti-inflammatory and antibacterial activities in animal wound infection models, thereby promoting healing, highlighting its therapeutic potential as a wound treatment.

Immune thrombocytopenia (ITP) is characterized by the overproduction of antiplatelet autoantibodies. Although B-cell depletion therapies show promise in ITP, their high relapse rates suggest a potential de novo breakdown of tolerance during an early stage of B-cell development. Here, we investigated how central B-cell tolerance mechanisms affect autoantibody production in ITP. Paired single-cell R

Detta kapitel ger en introduktion till digitala metoder inom idéhistoria, med särskilt fokus på hur studenter kan arbeta med text som data. Vi presenterar centrala begrepp som fjärrläsning, skalbar läsning och temamodellering, samt praktiska verktyg som Transkribus, RegEx och Voyant. Genom konkreta exempel visar vi hur digital textanalys kan identifiera mönster i stora textkorpusar och fungera som

Digital transformation of healthcare has largely been conceptualised throughadoption-centric lenses, relying on “barriers and facilitators” frameworks thatfocus primarily on individual technology adoption or organisational factors.Yet transformation in practice depends on sustained coordination amongmultiple autonomous actors who must align their actions across organisational,professional, and tec

The 1952 General Plan for Stockholm stands among Sweden’s most ambitious postwar planning documents, often cited as evidence for or against the large-scale ambitions of Welfare State modernism. Viewed through the lens of assemblage thinking, the plan does not appear as a self-referential, determinist blueprint subsuming social space. Instead, it is read as what this chapter calls a model assemblag

In this work, we derive the relationship between the states of strain and stress in pseudomorphic epitaxial layers on a substrate with differing equilibrium lattice parameters under symmetry-conserving conditions for the case of monoclinic crystal symmetry. We compare surface vectors across the template-epitaxial layer interface and impose conditions of a stress-free epitaxial layer. As a result,

After examining 4247 articles in 10 journals between 2010 and 2020, we found only 11.7% (n = 497) included explicit policy recommendations, and just 1.4% (n = 60) had explicit policy implications subsections. We analysed these 60 articles using behaviourally anchored rating scales (BARS) to assess four key aspects of the policy implications for quality and practicality. Policy implications were ge

Aim: To evaluate the impact of initial mono- versus multitherapy on the ocular surface and related quality of life after 5 years follow-up in the Glaucoma Intensive Treatment Study (GITS). Method: The study included patients with primary open-angle glaucoma and pseudoexfoliation glaucoma who completed 5-year follow-up in GITS. Assessment of ocular surface disease (OSD) symptoms was done using a Sw

Ledarskap har beskrivits som ett undflyende fenomen – en (positiv) lösning som kan kopplas till nästintill alla problem, men är svårt att fånga när det händer. Karisma, transformation och extraordinärisering utgör synsätt på ledarskap där särskilda individer tillskrivs extraordinära egenskaper, men de har inte fångat hur detta görs i vardagliga interaktioner. Ledarskap som praktik och ledarskap i Leadership has been described as a disappearing phenomenon – a (positive) solution that can be attached to almost any problem, yet it is difficult to capture as it happens. Charisma, transformation, and extra-ordinarization are perspectives on leadership where certain individuals are ascribed extraordinary qualities, but this is not captured analytically in everyday interactions. However, Leadersh

The extent to which public health interventions and medical innovations have improved population health has long been debated. This thesis addresses this question by examining anti‑tuberculosis (TB) campaigns—often considered the first modern public health campaigns—through the case study of twentieth‑century Sweden.The thesis begins by documenting the rise and fall of Sweden’s anti‑TB campaigns,

OBJECTIVE: To describe the distribution of HIV-1 variants in population-based national surveys conducted in sub-Saharan African countries between 2015 and 2022.DESIGN: Multicountry analysis.METHODS: Sixteen population-based national surveys, conducted between 2015 and 2022, were analyzed. Survey participants were eligible if HIV genotyping was successful. In most countries, people with HIV (PWH) w

Management of neonates with hypoplastic left heart syndrome following the Norwood procedure seeks to optimize systemic oxygen delivery while maintaining an appropriate distribution between systemic and pulmonary blood flow. The objective of this study was to quantify actively circulating blood volume, total cardiac output, the pulmonary-to-systemic blood flow ratio (Qp/Qs), and vascular resistance

Introduction: Present literature on professionalism usually focuses on individual parts of professional identity development and mostly, as these are seen and are evaluated by the dental educators. When looking at professionalism and in particular professional identity formation, It is extremely important to listen to the voice of the students regarding their thoughts, attitudes, beliefs and ideas

Introduction: Divers are reported to have a lower ventilatory response to elevated levels of carbon dioxide (CO₂) than non-divers. Hypoventilation with CO₂ retention during diving is potentially dangerous. It is unknown if CO₂ retention is largely inherited or develops during diving training. We aimed to investigate if a military dive training course would influence the ventilatory response to CO₂