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Background: It is unclear whether the two device-aided therapies (DATs: deep brain stimulation [DBS] and levodopa–carbidopa intestinal gel [LCIG]) affect personality in patients with Parkinson’s disease (PD). Objective: This retrospective study aims to explore if patients with PD and their close relatives experience any changes in the patient’s personality following the start of DAT. Methods: In t

This chapter describes the core concept sense of coherence (SOC), in terms of definition, measurement, distribution, dimensionality and stability over time. The extensive evidence base of research after Antonovsky died, shows that SOC is a multidimensional and culturally sensitive life orientation. To date, the SOC questionnaire has been used in at least 73 countries all over the world. In additio

Additive manufacturing (AM), particularly Laser Powder Bed Fusion, produces surfaces with unique, randomly distributed spherical roughness that significantly influences heat transfer and pressure loss. This study models AM roughness using a statistical distribution of spheres and performs high-fidelity simulations at a bulk Reynolds number of 12,000 to evaluate heat transfer on a rough pipe. Stati

Research on adolescent sexual orientation has expanded in recent decades, yet little is known about its associations with personality traits during this developmental period. This study examined personality dimensions, as measured by the Junior Temperament and Character Inventory, across adolescent sexual orientation groups (asexual, homosexual, heterosexual, bisexual) in a community-based sample

Background and aims: The aim of the present study is to examine the association between parenting practices and adolescent alcohol use in a longitudinal sample of adolescents from Sweden. Data and methods: A prospective longitudinal sample of 3,685 adolescents in a nationwide study in Sweden (2017-2019) filled out questionnaires. Baseline data (T1; 2017) was collected from participants at age 15 t

INTRODUCTION: Blood-based biomarkers have demonstrated high accuracy for identifying Alzheimer's disease (AD) pathology. However, the lack of representative cohorts creates a knowledge gap regarding their real-world applicability. We examined the influence of ethnicity on the diagnostic accuracy of plasma tau phosphorylated at threonine 217 (p-tau217) in identifying AD. METHODS: A total of 1170 mi

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective

Context. Studies of the internal kinematics of the LMC have provided a detailed view of its structure, largely thanks to the exquisite proper motion data supplied by the Gaia mission. However, line-of-sight (LoS) velocities, the third component of the stellar motion, are only available for a small subset of the current Gaia data, thus limiting studies of the kinematics perpendicular to the LMC dis

ImportanceThe genetic variation in patients with sensorineural hearing loss (SNHL) in the Nordic countries has not been previously reported.ObjectivesThe aim was to describe the genetic variation in a Swedish population and identify factors in favor of a high diagnostic yield.DesignThis was a prospective cohort study. Children with bilateral SNHL and adults with bilateral SNHL and clinically suspe

Purpose: To investigate the rates of knee reoperation and medical complications after meniscal repair versus partial meniscectomy (APM) up to 10 years after surgery. Methods: All patients ≥ 15 years old operated for a meniscal tear with meniscus repair or partial meniscectomy at Scania University Hospital were included, between year 2010 and 2014. Information was retrieved from patient records unt

Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionall

Motivation Efforts to address health disparities are often limited by the lack of robust computational tools for inferring genetic ancestry by calculating an individual's genetic similarity to continental groups. We have already shown that a preferred alternative to self-described race is using ancestry-informative markers (AIMs) that can be classified into ancestral components and used to estimat

Magnetic resonance imaging (MRI) enables non-invasive monitoring of healthy brain development and disease. Widely used higher field (>1.5 T) MRI systems are associated with high energy and infrastructure requirements, and high costs. Recent ultra-low-field (<0.1 T) systems provide a more accessible and cost-effective alternative. However, it remains uncertain whether anatomical ultra-low-field neu

This study examines the effectiveness of LU-PZE, a web-based interactive tool designed to help students visualize and interact with fundamental concepts in automatic control. A total of 200 students enrolled in an introductory course on automatic control had the option to use LU-PZE as an additional resource for learning. LU-PZE offers users randomized quizzes, structured assignments, and real-tim

Cytological analysis of a series of Streptomyces coelicolor A3(2) mutants with disruptions of early sporulation (whi, for white aerial mycelium) genes in an isogenic background has provided new information about the role of whiH, and confirmed and extended previous knowledge about whiG, whiA and whiB. The characteristic straight aerial hyphae of whiG mutants contained normally spaced vegetative-li

Introduction As care and rehabilitation poststroke are increasingly moving into persons’ home environment, the importance of support from social networks in self-management and rehabilitation has emerged as an important topic for research and practice. While there are instruments used to assess social support and collective efficacy, a clearer scope of the availability and quality of these instrum

The differentiation of Streptomyces aerial hyphae into chains of unigenomic spores occurs through the synchronous formation of multiple FtsZ rings, leading to sporulation septa. We show here that developmental control of ftsZ transcription is required for sporulation in Streptomyces coelicolor A3(2). Three putative ftsZ promoters were detected in the ftsQ-ftsZ intergenic region. In addition, some

We investigated the element-specific electronic structure and charge-carrier dynamics of a single-crystal ferromagnet CoS2 with complementary x-ray spectroscopy techniques. Hard x-ray photoemission (HAXPES) is used to provide crucial information on the bulk electronic structure and chemical bonding in CoS2 that is compared against the isoelectronic paramagnet CoSe2. The Co 1s core-level line shows