Search results

Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r

UNLABELLED: In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting enzalutamide monotherapy from patients with high

This editorial introduces the special issue on the geography of innovation and sustainability transitions in the bioeconomy, situating the bioeconomy as a policy-driven transformation project with strong regional and multi-scalar implications. The special issue contains six papers that focus on different parts of the bioeconomy and employ a wide range of empirical approaches; jointly, they provide

Natural products originating from microorganisms have been an important source of many successful lead molecules in the drug discovery and development process. The technological advances in analytical instrumentation and the development of various omics methodologies have provided new opportunities to accelerate the discoveries of new lead structures of microbial origin. Metabolomics is a rapidly

Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC). However, the variability of TROP2 expression across different bladder cancer (BC) subtypes, as well as after enfortumab vedotin (EV) exposure, remains unknown. Using gene expression data from four clinical cohorts with >1400 pa

Objective: To assess the risk of suicide after a diagnosis of urinary bladder cancer (UBC) compared with the standard population and to identify potential risk factors and time dependence associated with suicide in patients with UBC. Method: We used data from the Bladder Cancer Data Base Sweden 2.0 (BladderBaSe), including all individuals aged 18 years or older, diagnosed with UBC between 1997 and

Urban Living Labs (ULLs) are widely promoted as experimental spaces for urban innovation, particularly in EU policy contexts. Yet their design is often shaped by current institutional logics, EU-funding structures, and sector-specific constraints, especially in transport, a domain marked by technical path dependencies and dominant narratives of efficiency and optimization. These conditions risk naUrban Living Labs (ULLs) are widely promoted as experimental spaces for urban innovation, particularly in EU policy contexts. Yet their design is often shaped by current institutional logics, EU-funding structures, and sector-specific constraints, especially in transport, a domain marked by technical path dependencies and dominant narratives of efficiency and optimization. These conditions risk na

Background: The evidence-based Canadian Adult Obesity Clinical Practice Guideline (CPG) released in August 2020 were developed through a systematic literature review and patient-oriented research process. This CPG is considered a paradigm shift for obesity care as it introduced a new obesity definition that is based on health not body size, incorporates lived experiences of people affected by obes

Background: Approximately 15% of Canadian adults live with two or more chronic diseases, many of which are obesity related. The degree to which Canadian obesity treatment guidelines are integrated into chronic disease management is unknown. Methods: We conducted a 12-min online survey among a non-probability sample of 2506 adult Canadians who met at least one of the following criteria: 1) BMI ≥30

Introduction: Being stigmatized because of one's weight can pose physical, mental, and social challenges. While weight stigma and its consequences are established throughout Europe, North America, and Australasia, less is known about weight stigma in other regions. The objective of this study was to identify the extent and focus of weight stigma research in Latin America, Asia, the Middle East, an

We report the first experimental observation of carrier-envelope phase-driven energy bunching in laser wakefield acceleration. Using a few-cycle (∼9 fs), multiterawatt laser pulse and ionization injection in a helium-nitrogen gas mixture, we observe electron spectra composed of multiple quasimonoenergetic peaks with regular narrow energy spacing. This comb structure arises from intermittent trappi

This book provides a critique of David Harvey's theory of land rent and his replacement of Marx's concept of absolute rent with class-monopoly rent, arguing that this shift inadequately addresses crucial theoretical and empirical problems in urban economic geography today. The alternative introduced links land rent to fluctuations in profit rates rather than monopoly pricing. Land Rent, Capital, R

High-pressure blocking events are anticyclones that persist over a region for a long time. Such events prevent vertical mixing of air pollutants due to the subsidence inversion created by the anticyclone. This study investigates the relationship of aerosol concentrations during periods of high-pressure blocking events in southern Sweden for the rural location of Vavihill and the urban location of

Aerosol-cloud interactions (ACI) are a major source of uncertainty in climate science, critically affecting our ability to project near-term climate evolution and assess societal risks. These interactions influence effective radiative forcing, cloud dynamics, and precipitation patterns, yet remain insufficiently constrained due to limitations in observations, modeling, and process understanding. T

The GERD has been a focal point of hydropolitical tensions in the Nile River Basin, primarily involving Ethiopia, Sudan, and Egypt. This article examines Sudan’s unique position and role as a potential mediator in this tripartite dispute. Khartoum’s mediation role, driven by its own vested interests in the dam’s operation, including benefits from regulated flood control, electricity generation and

Objective: Mounting evidence supports an association between the intestinal microbiota and diverse pulmonary pathologies (ie, gut-lung axis). Although intestinal dysbiosis is a feature of systemic sclerosis (SSc), no prior studies have investigated the relationship between intestinal microbiota and SSc-associated interstitial lung disease (ILD) in a multinational cohort. This study aimed to charac

Background: Explicit weight bias is known as negative attitudes and beliefs toward individuals due to their weight status and can be perpetuated through misconceptions about the causes of obesity. Individuals may also experience weight bias internalization (WBI) when they internalize negative weight-related attitudes and self-stigmatize. There is a paucity of research on the beliefs about the caus

OBJECTIVE: Body dissatisfaction in pregnancy has been associated with negative psychological maternal outcomes, including increased risk of postpartum depression. This study aimed to explore weight-related factors that influence body dissatisfaction in pregnancy, including gestational weight gain (GWG), weight stigma, obesity, and weight loss attempts before pregnancy.DESIGN: Secondary analysis of