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The receptor pharmacology of amperozide was investigated with in vitro radioligand binding technique. Amperozide possessed a high affinity to the 5-HT2 receptors (Ki = 16.5 +/- 2.1 nM) and a moderate affinity to alpha 1-adrenergic receptors of rat cerebral cortical membranes (Ki = 172 +/- 14 nM). The affinity of amperozide for striatal and limbic dopamine D2 receptors was low and not significantly
Leaching of dissolved organic carbon (DOC) from the forest floor and transport in soil solution into the mineral soil are important for carbon cycling in boreal forest ecosystems. We examined DOC concentrations in bulk deposition, throughfall and in soil solutions collected under the O and B horizons in three Norway spruce stands along a climatic gradient in Sweden. Mean annual temperature for the
The nature of the intermolecular and substrate bonds of iron phthalocyanine adsorbed on highly oriented pyrolitic graphite has been investigated by x-ray photoelectron spectroscopy and x-ray absorption spectroscopy. We find that the molecules grow in a highly ordered fashion with the molecules essentially plane-parallel to the surface in both the mono- and multilayers. The spectra obtained on both
Objectives: Low serum 25-hydroxyviatmin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our
The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a s
An evaluation has been made of the capability of rapeseed oil to dissolve polycyclic aromatic hydrocarbon (PAH) crystals in a biphasic system and of its capability to extract PAHs from polluted soil in a two-liquid-phase (TLP) slurry system. Up to 220 g l(-1) of the crystalline hydrocarbons could be dissolved in the organic phase, indicating oil/water-partitioning coefficients of 10(5). When soil
To predict maximal exercise capacity, we have developed the rating of perceived capacity (RPC) scale, based on metabolic equivalents (METs). MET values from 1 to 20 were listed on a progressive scale and linked to physical activities. Test subjects rated their perceived capacity by choosing the most strenuous activity and the corresponding MET value that they could sustain for 30 min. In order to
We propose Cholesky decomposition (CD) of the atomic two-electron integral matrix as a robust and general technique for generating auxiliary basis sets for the density fitting approximation. The atomic CD (aCD) auxiliary basis set is calculated on the fly and is not biased toward a particular quantum chemical method. Moreover, the accuracy of the aCD basis set can be controlled with a single param
The dynamic vegetation model (LPJ-GUESS) is used to project transient impacts of changes in climate on vegetation of the Barents Region. We incorporate additional plant functional types, i.e. shrubs and defined different types of open ground vegetation, to improve the representation of arctic vegetation in the global model. We use future climate projections as well as control climate data for 1981
We, present a one-step technology for fabrication of Topas-based lab-on-a-chip (LOC) microsysterris by the use of thermal nanoimprint lithography (NIL). The technology is demonstrated by the fabrication of two working devices: a particle separator and a LOC with integrated optics for absorbance measurements. These applications demonstrate the fabrication of millimeter to micrometer-sized structure
Persistent pollutants in an Atlantic salmon (Salmo salar) population spawning in a river of southern Sweden were investigated. The population was characterized by a high growth rate. Some males reached 20-30 kg after 3 to 4 years in the sea. The fat content of migrating salmon varied by one order of magnitude and was the most significant correlate of pollutant concentrations. No relationships were
Stimulation of rat adipocytes with insulin and isoproterenol results in serine phosphorylation and activation of the adipocyte cGMP-inhibited phosphodiesterase (cGI PDE), events believed to be important in the antilipolytic action of insulin (Degerman, E., Smith, C.J., Tornqvist, H., Vasta, V., Manganiello, V.C., and Belfrage, P. (1990) Proc. Natl. Acad. Sci. U.S.A. 87,533-537). Here we demonstrat
The classical derivation of a traffic stream model (e.g. speed/concentration relation) from the equilibrium solutions of the Prigogine–Herman kinetic equation invokes the nontrivial assumption that the underlying distribution of desired speeds is nonzero for vanishingly small speeds. In this paper we investigate the situation when this assumption does not hold. It is found that the Prigogine–Herma
The overall pattern of deglaciation of the southern part of the Scandinavian Ice Sheet has been considered established, although details of the chronology and ice sheet dynamics are less well known. Even less is known for the south Swedish Upland because the area was deglaciated mostly by stagnation. Within this area lies the conspicuous Vimmerby moraine, for which we have used the terrestrial cos
The basic helix-loop-helix (bHLH) proteins control differentiation and development of a variety of organs. We have isolated the complementary DNA (cDNA) of a novel class of bHLH transcription factors. The previously uncharacterized bHLH messenger RNA (mRNA) was identified by RNA fingerprinting by comparing embryonic and adult mRNA. The reading frame sequence predicts a new class of bHLH family. No
Myocardial perfusion imaging with single-photon emission computed tomography (SPECT) is useful for the evaluation of patients with known or suspected coronary artery disease. Parameters of interest are the reduction in the blood perfusion (severity) and the lesion volume (extent). The aim of this study was to evaluate these parameters, as calculated by automatic quantification software, for differ
Multilevel flow models (MFM) are graphical models of goals and functions of technical systems. MFM was invented by Morten Lind at the Technical University of Denmark and several new algorithms and implementations have been contributed by the group headed by Jan Eric Larsson at Lund Institute of Technology. MFM has several properties which makes for a relatively easy knowledge engineering task, com
Handheld mobile phones were introduced in Denmark and Sweden during the late 1980s. This makes the Danish and Swedish populations suitable for a study aimed at testing the hypothesis that long-term mobile phone use increases the risk of parotid gland tumors. In this population-based case-control study, the authors identified all cases aged 20-69 years diagnosed with parotid gland tumor during 2000
Pseudomonas putida DSM 50026 cells were used as the biological component and the measurement was based on the respiratory activity of the cells estimated from electrochemical measurements. The cells were immobilised on carbon nanotube (CNT) modified carbon paste electrodes (CPE) by means of a redox osmium polymer, viz. poly(1-vinylimidazole)(12)-[Os-(4,4'-dimethyl-2,2'-dipyridyl)(2)Cl-2](2+ /+). T
