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Alternative oxidase (AOX) is a non-mammalian enzyme that can bypass blockade of the complex III-IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)-deficient Bcs1lp.S78G knock-in mice, displaying multiple visceral manifestations and premature death. The homozygotes expressing AOX were viable, and their median survival was extended from
Two different hypotheses about cell of origin of breast cancer have been proposed. One theory states that breast cancer originates from an epithelial stem cell and subsequent genetic changes determine the phenotype, while another hypothesis postulates that breast cancer could originate from different cells, both stem cells and progenitor cells. Therefore, the phenotype in the latter situation is p
Background. Alcohol use disorders are a major health problem, often with a chronic course. Studies on remission from alcohol use disorders are sparse. Objective. The aim of this study was to analyse the rate of remission from AUD and the possible influence of other mental disorders and sociodemographic factors on the remission in the Lundby Cohort. Method. Remission from AUD was studied for 312 ma
Chronic wounds are a health problem that have devastating consequences for patients and contribute major costs to healthcare systems and societies. To understand the magnitude of this health issue, a systematic review was undertaken. Searches were conducted in MEDLINE, EMBASE, EBM Reviews and Cochrane library, CINAHL, EBSCO, PsycINFO, and Global Health databases for articles published between 2000
Background. Opioid agonist treatment (OAT), for the treatment of heroin dependence, has been reported to improve overall health and lower mortality. Drug use and retention in treatment have often been used as measures of treatment success. More recently, however, researchers have suggested that measurements of quality of life should be an outcome in substance use treatment evaluations. In a recent
I artikeln diskuteras villkoren för progression i historia och hur detta slags progression kan identifieras.
Introduction: Tumour stage is the most important prognostic factor in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The aim of this study was to evaluate if female gender was a prognostic factor in different tumour stages in relation to histology and given therapy. Methods: From 1989-2008, 1497 patients in eastern Scania, in southern Sweden with 202,000 inhabitants, were re
Recension av Dina & Jovan Rajs, Att återvända till livet
The concrete structure of a reactor containment is pre-stressed with tendonsplaced in ducts. In some reactor containments, these ducts are injected withcement grout after pre-stressing. The cement grout protects the tendonsagainst corrosion and has the potential to redistribute the stresses in a tendon in the case of wire failure. The disadvantage of injected ducts is that the tendons pre-stressin
Recension av Carin Bergström, Albertina och Viktor – emigranterna som återvände
Recension av Gunnar Artéus, Anna Maria Lenngren – ett kvinnoliv
Notwithstanding its many successes since 1945, the project of European integration currently faces major difficulties, from financial crises and mass immigration to the impending departure of the UK from the European Union. At the same time, these challenges have spurred civil society organizations within and across Europe, revealing a shared public sphere in which citizens can mobilize around ref
