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BACKGROUND AND OBJECTIVE: A post hoc analysis of TITAN evaluated the clinical benefit of apalutamide plus androgen-deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (mHSPC) with high disease burden. METHODS: Patients were assessed in subgroups of those with four to fewer than ten, ten to <20, or ≥20 bone metastases; with lung but not liver metastases; and w

An approach to reducing greenhouse gas emissions that shows promise is the electrochemical conversion of CO2 to products with added value. Here, we present [Co(8HQ-Tpy)(H2 O)]2 (PF6 )2 ([Co1]), a cobalt-based molecular electrocatalyst that can convert CO2 to CO in a DMF/H2 O mixture (4.8 : 0.2 v/v) in a selective manner (8HQ-Tpy = 2-([2,2′:6′,2′′-terpyridin]-4′-yl)quinolin-8-ol). At an overpotenti

This is the Replicated Computational Results (RCR) Report for the article ‘Stress Testing Control Loops in Cyber-Physical Systems’. The article proposes a novel approach for testing Cyber-Physical Systems (CPS) based on the integration of the guarantees that can be provided with the control theoretical models into the software testing practices. This RCR report describes how to reproduce the empir

AIM: We aimed to investigate if the incidence of type 1 diabetes increased in children during the SARS-CoV-2 pandemic and whether SARS-CoV-2 antibodies were more frequently present at diagnosis compared with healthy individuals. We also examined whether clinical characteristics and coexisting autoimmunity differed between SARS-CoV-2 antibody positive and negative individuals.METHODS: This retrospe

Spill och dolda kostnader äter upp enorma resurser i industrin. Genom att anpassa Toyotas berömda Lean-metoder för plastfilmstillverkning hittar detta arbete verktygen för att avslöja de dolda kostnaderna och minska slöseriet. Föreställ dig ett isberg. Ovanför vattenytan syns toppen, de uppenbara kostnaderna där material slängs, eller när en maskin går sönder och måste repareras. Men under ytan This master thesis investigates the feasibility of utilizing Lean Manufacturing Principles, derived from traditional discrete manufacturing to enhance efficiency and reduce waste within a continuous process industry environment at Graphic Packaging Flexibles (GPI) in Lund. The company produces fiber- and plastic-based packaging solutions and faces challenges regarding waste. The purpose of this st

This paper explores how the regional policies of Sweden and Norway have impactedthe respective peripheral regions of Västerbotten and Troms. There is a variety ofmaterial used in this text, ranging from government white papers, policy documents,statistical data taken from governmental databases. The theory of CumulativeCausation as well as the analytical framework of Historical Institutionalism wi

Detta examensarbete presenterar resultatet av en utredning av ihopspänningen av en packningsförsedd plattvärmeväxlare. Projektets huvudfokus var att hitta en ny metod för att spänna ihop en packningsförsedd värmeväxlare some är mer exakt än den nuvarande metoden. Detta åstadkomms genom att ta hänsyn till tillverkningstoleranserna av de ingående delarna. Andra faktorer som antalet kanalplattor, matThis thesis presents the results of an investigation of the tightening function of a gasketed plate heat exchanger (GPHE). The main focus of the project has been to find a new method for tightening a GPHE that is more accurate than the current method. This is achieved by factoring in manufacturing tolerances of the ingoing parts. Other factors such as the number of channel plates, channel plate ma

Uppsatsen behandlar hur Rysslands president Vladimir Putin legitimerar in-vasionen av Ukraina genom historiska narrativ i kontrast till non-interventionsprincipen. Med utgångspunkt i ett rättshistorisk perspektiv utförs en diskurshistorisk analys tillsammans med historiedidaktisk ansats för att undersöka hur dessa argument förhåller sig till non-interventionsprincipen. Analysen grundar sig på fyraThe thesis examines how the President of the Russian Federation, Vladimir Putin, seeks to legitimize the invasion of Ukraine through historical narratives and legal arguments. By applying a legal-historical approach combined with discourse-historical analysis, the study investigates how these narratives and arguments relate to the principle of non-intervention in international law. The analysis is

Aktierelaterade incitamentsprogram är mycket vanligt förekommande bland svenska bolag och kan användas för att attrahera, motivera och behålla anställda och nyckelpersoner. Programmen innebär att deltagaren tilldelas en villkorad rätt till ersättning som är knuten till aktier, aktiekursen eller andra finansiella instrument utgivna av arbetsgivarbolaget eller dess koncern. Civilrättsligt kan prograStock incentive plans are commonly used by Swedish companies to attract, motivate, and retain employees and executives. Under such plans, participants are granted a conditional right to compensation related to shares, share prices, or other financial instruments issued by the employer company or entities within its group. These plans are generally divided into contractual plans and dilution-based

How Do We Treat the Super-Elderly with Distal Radius Fractures and What is the Outcome? A Register Study in 239 Patients of 80 years or olderLinnea Sara Arvidsson, MD; Ellen Lööf, Bachelor of Medicine; Antonio Abramo, PhD; Magnus Tägil, PhDLund University, Lund, SwedenIntroductionWith a rapidly ageing population, the number of wrist fractures will rise dramatically in the super elderly group. BasiIntroductionWith a rapidly ageing population, the number of wrist fractures will rise dramatically in the super elderly group. Basic knowledge of outcome after fracture in this heterogenic group is absent. Our aim was to use our prospective distal radius fracture register to study the super-elderly patients with distal radius fractures. We hypothesized that the health status of the patient, rather

Purpose: Direct laryngoscopy (DL) is the standard technique for endotracheal intubation. Video-assisted laryngoscopy (VL) has emerged as an alternative, particularly for difficult airway management. Nevertheless, DL and VL have not been systematically compared for simulation-based endotracheal intubation by inexperienced operators. Method: A prospective, randomized cross-over study was carried out

BackgroundRight ventricular–pulmonary arterial (RV–PA) uncoupling is central to prognosis in precapillary pulmonary hypertension (PH). While the tricuspid annular plane systolic excursion tosystolic pulmonary artery pressure (TAPSE/sPAP) ratio is an established bedside surrogate of RV–PA coupling, novel energetic markers such as three-dimensional (3D)–derived right ventricular (RV) global wasted w

BACKGROUND: Tumour deposits are an important prognostic factor in colorectal cancer. In tumour node metastasis (TNM)8, the definition became stricter as TNM7's previous requirement for absence of lymphatic tissue was expanded to also include nerve and vascular tissue. TNM8 has been criticised for its limited prognostic value. This study aimed to compare prognostic differences for patients with col

Background:With a rapidly ageing population, the number of wrist fractures will rise dramatically in the super-elderly (>80 years) group. In previous published studies regarding mortality after wrist fractures elderly are often defined using a rather wide age-span, the threshold has been set to somewhere between 50-70 years. However, elderly defined as a group this way is probably too imprecise. D

In this study, I have examined the Cathars’ understanding of salvation, and in particular the role that Jesus has in their idea of salvation. I do this by analysing Cathar sources from the 12th and 13th centuries to which I apply a hermeneutical theory and method. Throughout my analysis I examined the source material individually and identified salvation themes that previous scholars have identifi

I ett aktiebolag har aktieägarna inte något personligt betalningsansvar för bolagets förpliktelser, vilket framgår av 1 kap. 3 § aktiebolagslagen (2005:551) (ABL). Ak- tieägarnas frihet från personligt betalningsansvar balanseras av lagregler som skyd- dar bolagets borgenärer. I doktrin och förarbeten har det även diskuterats om ak- tieägare eller andra trots huvudregeln i 1 kap. 3 § ABL, med stödIn a limited liability company, shareholders do not have personal liability for the company’s obligations, as stated in Chapter 1, Section 3 of the Swedish Companies Act (2005:551) (ABL). Shareholders’ exemption from personal liability is balanced by statutory rules protecting the company’s creditors. In doctrine and preparatory works, it has also been discussed whether shareholders or others, des

Utmattning har under de senaste åren blivit en av de vanligaste orsakerna till sjukfrånvaro i Sverige, vilket medför konsekvenser på såväl individuell som organisatorisk och samhällsekonomisk nivå. Syftet med studien var att undersöka hur upplevda arbetskrav, kontroll, socialt stöd och prestationsbaserad självkänsla (PBS) påverkar risken för utmattning bland yrkesverksamma i Sverige. Data samladesIn recent years, exhaustion disorder has become one of the most common causes of sick leave in Sweden, leading to consequences at individual, organizational and socioeconomic levels. The aim of this study was to investigate how perceived work demands, control, social support and performance-based self-esteem (PBSE) affect the risk of exhaustion among working people in Sweden. Data was collected th

This paper explores identity, personhood and sickness through a postcolonial lens in regards to the literary pop-cultural zombie in the 21st century. The zombie figure is studied in regards to theories of "the other" and "othering" as well as sociological and literary theories about illness, the paper thus falls within the field of medical humanities. Questions about identity,

Quantum mechanics forbids perfect discrimination of non-orthogonal states, a limitation that can be exploited to certify intrinsic randomness. Building on this principle, this thesis investigates how limits on state discrimination can be used to generate certified randomness in prepare-and-measure protocols. In particular, we study how the performance of minimum-error quantum state discrimination

Studiens huvudsakliga syfte är att undersöka hur HR-personal i praktiken hanterar och skapar tillit till AI-baserade system samt hur detta samspel påverkar HR professionen, legitimitet och kommunikation inom organisationen. Genom att belysa HR:s roll bidrar studien till en djupare förståelse för hur yrkesrollen omformas i en digitaliserad värld. Studien utgår från ett interpretativt perspektiv med