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The ANKA storage ring of the Karlsruhe Institute of Technology (KIT) operates in the energy range from 0.5 to 2.5 GeV and generates brilliant coherent synchrotron radiation in the THz range with a dedicated bunch length reducing optic. The producing of radiation in the so-called THz-gap is challenging, but this intense THz radiation is very attractive for certain user experiments. The high degree
At the KIT storage ring KARA (KArlsruhe Research Accelerator), the momentum compaction factor can be reduced leading to natural bunch lengths in the ps range. Due to the high degree of longitudinal compression, the micro-bunching instability arises. During this longitudinal instability, the bunches emit bursts of intense coherent synchrotron radiation in the THz frequency range caused by the compl
At KARA, the Karlsruhe Research Accelerator of the Karlsruhe Institute of Technology synchrotron, the so-called short-bunch operation mode allows the reduction of the bunch length down to a few picoseconds. The microbunching instability resulting from the high degree of longitudinal compression leads to fluctuations in the emitted terahertz radiation, referred to as bursting. For extremely compres
At ANKA, the Karlsruhe synchrotron radiation source, the so called short bunch-length operation mode allows the reduction of the bunch length down to a few picoseconds. The micro-bunching instability resulting from the high degree of longitudinal compression leads to fluctuations in the emitted intensity in the THz regime, referred to as bursting. For extremely compressed bunches at ANKA bursting
Dedicated optics with extremely short electron bunches enable synchrotron light sources to generate intense coherent THz radiation. The high degree of spatial compression in this so-called low-αc optics entails a complex longitudinal dynamics of the electron bunches, which can be probed studying the fluctuations in the emitted terahertz radiation caused by the microbunching instability ("bursting"
Using firm-level data from 15 European countries between 2011 and 2019, this paper examines the productivity effect associated with the development of Artificial Intelligence (AI), measured by patenting success in AI fields. By making advances in AI and expanding on their knowledge base, companies can optimise production tasks, and improve resource utilisation, ultimately leading to higher levels
Wildfire evacuation is a life-saving measure of last resort, but delays can lead to dire outcomes, putting people at risk of fire entrapment. The success or failure of an evacuation depends on the relative speeds of the wildfire and the evacuation, and this varies across communities and wildfires. Despite the importance of understanding this dynamic, no formal framework exists to define or quantif
Background: Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in real-world clinical practice, however, remains to be established. The aim of the TAP-TAU study is therefore to investigate the impact of tau-PET in clinical practic
The use of studded tires can cause significant wear of road surfaces then also affect the air quality in urban areas. The studs of today's studded tires are manufactured from hard metal containing cobalt. In this study, we investigated using alternative cobalt-free hard metal studs to reduce particulate emissions in the future. The tire-to-road interface is subjected to both impact wear and slidin
Understanding the electrophysiological properties of antidepressant medications is important to resolve the response heterogeneity of these drugs in clinical practice. Administration of paroxetine, a selective serotonin reuptake inhibitor, has been shown to increase serotonin levels that affect cortical activities in healthy subjects. However, the extent to which cortical oscillations can be alter
The aim of this chapter is to explore the safety value of implementing Asimov's Laws of Robotics as a future general framework that humans should obey. Asimov formulated laws to make explicit the safeguards of the robots in his stories: (1) A robot may not injure or harm a human being or, through inaction, allow a human being to come to harm; (2) A robot must obey the orders given to it by human b
In this article, we analyse implicit connections between gender equality and particular forms of religion in Sweden, as expressed in political discourse and social media debates. Instagram posts responding to the Christian Democrats [Kristdemokraterna] political party’s proposal to ban the wearing of veils in Swedish primary schools in 2021 were analysed through methods of co-occurrence analysis a
Objective: Vaginal hysterectomy combined with uterosacral suspension (USLS) is a technique for treating pelvic organ prolapse. Vaginal natural orifice transluminal endoscopic surgery (vNOTES) has been described as an alternative minimal invasive approachfor treating various gynecological and non-gynecological pathologies. The aim was to compare the surgical time between conventional vaginal hyster
Addressing the risks of cyanobacterial blooms and toxin production under ongoing and accelerating eutrophication and climate warming is crucial for both water ecosystem services and human health. Therefore, we here explored the interactive effects of eutrophication and warming on freshwater ecosystems, focusing on Microcystis and its cyanotoxin production. We employed a large-scale mesocosm system
Background: Uric acid closely relates to both kidney disease and atrial fibrillation (AF), yet the extent to which it influences the kidney-AF association remains uncertain. We examined the relationship between kidney function and risk of AF, accounting for uric acid levels. Methods: A total of 308,509 individuals in the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) cohort were included a
Background. Kidney involvement is common in anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) and the prognosis is determined by the severity of kidney damage. This study focused on long-term kidney outcomes, defining possible risk factors and comparing the performance of three different histological classifications to predict outcomes for patients with AAV. Methods. The dataset inclu
Despite an advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of ribosome assembly in leukemia cell function. We apply patient datasets and murine models to demonstrate that immature leukemia cells in mixed-lineage leukemia-rearranged AML are characterized by relative
Hybrid e-learning offered flexibility for students who could not attend in-person classes during the COVID-19 pandemic, but its effectiveness in teaching chest physiotherapy remains to be determined. This retrospective case-control study assessed physiotherapy students’ academic performance and satisfaction with a hybrid classroom approach adopted during the COVID-19 pandemic for teaching airway c
The field of oncobiology is witnessing rapid progress, with numerous ongoing studies dedicated to comprehending the intricate mechanisms underlying cancer initiation, progression, and therapeutic interventions. Despite significant strides, there remains a substantial gap in fully understanding the multifaceted factors driving cancer development and trajectory. This chapter delves into the imperati
