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Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL an
BACKGROUND: Mosaic loss of chromosome Y (LOY) is associated with cardiovascular and neurodegenerative diseases in men, and genetic predisposition to LOY is associated with poor poststroke outcome. We, therefore, tested the hypothesis that LOY itself is associated with functional outcome after ischemic stroke. METHODS: The study comprised male patients with ischemic stroke from the cohort studies S
Background: The application of Pulsed Electric Field (PEF) to food may result in reversible or irreversible electroporation of cell membranes, depending on whether cell homeostasis is restored after resealing. Restoration of homeostasis upon reversible electroporation implies the recovery of the pre-pulse transmembrane potential and the restoration of cell metabolic functions. Enhanced membrane pe
Samhällsvetenskapliga fakulteten vid Lunds universitet instämmer i huvudsak i utredningens slutsatser, men anser att regeringen i samarbete med arbetsmarknadens parter bör överväga åtgärder om kollektivavtalens täckningsgrad skulle börja sjunka och långt innan den kommer ned på tröskelvärdet 80%. Den svenska arbetsmarknadsmodellen vilar, förutom på en hög kollektivavtalstäckning, också på en hög o
Purpose: Aim of this study was to evaluate the effect of intravenous Y27632 (a ROK inhibitor) on intra-ureteral pressures and on blood pressure in an in vivo rat model for unilateral partial ureteral obstruction (PUO). Methods: 15 Male Sprague Dawley rats were used. Under isofluran anesthesia, saline was continuously infused via polyethylene (PE)-10 catheters inserted in the ureters beneath the ki
Although shared e-scooters have displayed both complementary and competitive relationships with public transport, less attention has been paid to investigating the spatiotemporal variations of such relationships, and how the relationships are associated with the urban built environment. To bridge the gaps, we first explore the spatiotemporal heterogeneity of such relationships by conducting a comp
Background and ObjectivesWhile chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age."We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of patients with stroke will be associated with cardiovascular risk factors a
Objective: Abdominal aortic graft and endograft infections (AGIs) are rare complications following aortic surgery. Radical surgery (RS) with resection of the infected graft and reconstruction with extra-anatomical bypass or in situ reconstruction is the preferred therapy. For patients unfit for RS, a semi-conservative (SC), graft preserving strategy is possible. This paper aimed to compare surviva
Enkelt uttryckt är Samverkansinlärning (SI) en studiecirkel kopplat till en utmanande kurs. SI leds av en senior student som utformar läraktiviteter där studenterna arbetar i grupper med att förklara och förtydliga svårt kursmaterial. Målsättningen med SI, förutom förbättrade prestationer i den aktuella kursen, är att studenterna skall utveckla goda studiestrategier och bli mer självständiga i sit
Lytic polysaccharide monooxygenases (LPMOs) are surface-active redox enzymes that catalyze the degradation of recalcitrant polysaccharides, making them important tools for energy production from renewable sources. In addition, LPMOs are important virulence factors for fungi, bacteria, and viruses. However, many knowledge gaps still exist regarding their catalytic mechanism and interaction with the
Deaf and hard of hearing children with cochlear implants (CI) often display impaired spoken language skills. While a large number of studies investigated brain responses to sounds in this population, relatively few focused on semantic processing. Here we summarize and discuss findings in four studies of the N400, a cortical response that reflects semantic processing, in children with CI. A study w
Despite growing interest in fungal necromass decomposition due to its importance in soil carbon retention, whether a consistent group of microorganisms is associated with decomposing necromass remains unresolved. Here, we synthesize knowledge on the composition of the bacterial and fungal communities present on decomposing fungal necromass from a variety of fungal species, geographic locations, ha
The transport sector is currently undergoing rapid development, which is to a large extent driven by innovation and technological changes initiated by various market actors. At the same time, public transport operations are largely framed by extensive procurement processes and a mature market where a few large companies compete for market share. In Europe, there is tension between rapid innovative
The Swedish electric vehicle fleet is rapidly growing, creating a need to include their charging demand in future grid planning. Charging stations are often placed based on the needs of the transport system, and the grid connection is considered at a later stage with long lead times. This study proposes selecting charging locations based on grid capacity. Doing this by probabilistic load flow requ
OBJECTIVES: Evidence on dietary effects on gastrointestinal (GI) symptoms in healthy children is lacking. Despite this, dietary advice is still common practice in the treatment of children's GI symptoms. The aim was to investigate self-reported dietary effects on GI symptoms in healthy children. METHODS: In this observational cross-sectional study on children, a validated self-reporting questionna
Recently, the PHENIX Collaboration has published second- and third-harmonic Fourier coefficients v2 and v3 for midrapidity (|η|
The measurement of direct photons from Au+Au collisions at sNN=39 and 62.4 GeV in the transverse-momentum range 0.4
