Search results

The gain of neurotoxic function in amyotrophic lateral sclerosis (ALS) has been linked to misfolding of the homodimeric enzyme Cu/Zn superoxide dismutase (SOD). Here, we present the crystal structure of fully cysteine-depleted human SOD (SOD (CallA)), representing a reduced, marginally stable intermediate on the folding pathway in vivo that has also been implicated as neurotoxic precursor state. A

BACKGROUND: Numerous studies have shown that exposure to air pollutants in the area of residence and the socio-economic status of an individual may be related. Therefore, when conducting an epidemiological study on the health effect of air pollution, socio-economy may act as a confounding factor. In this paper we examine to what extent socio-economic status and concentrations of NO2 in the county/

We determined plasma lipid and lipoprotein concentrations in 131 patients (95 males, 36 females, mean age 71 years) 6 months after acute stroke onset. Compared to a reference population, the alterations of plasma lipid concentrations in stroke patients were moderate. However, the stroke patients had higher levels of triglyceride and lipoprotein (a) and lower concentrations of cholesterol, high den

Den övergripande målsättningen med projektet har varit att utifrån en prototyp av OE-staven ta fram ett fungerande mätsystem som håller jämförbar standard med dagens RF-mätningar. OE-metoden har visat sig uppfylla dessa krav och samtidigt vara ett kraftfullt verktyg för mätningar av RF-profiler i betongkonstruktioner. OE-metoden lämpar sig bäst att användas i svårbemästrade mätsituationer samt i s

Lumenal entry of plasma (mucosal exudation) is a key feature of airway inflammation. In airways challenged with histamine-type mediators and allergen the mucosal exudation response occurs without causing epithelial derangement and without increased airway absorption. In contrast, reactive oxygen metabolites may cause mucosal damage. In this study, involving guinea-pig airways, we have examined eff

A method for determining transition matrices for inhomogeneous dielectric shells is presented. The source can be either inside or outside the shell. The method is based upon expansions of the electric and magnetic fields in vector spherical harmonics. The expansion coefficients in the shell satisfy a system of linear ordinary differential equations in the radial direction. The expansion coefficien

Evidence-based medicine is a corner stone in treatment decision making and large randomised, clinical trials are usually designed in order-to provide highly significant results. This study was conducted in order to find out to what extend a "real life" patient population with obstructive lung disease could fit into criteria commonly used in clinical research trials. As a secondary aim of the study

Caloplaca sqtthfca Khodosovtsev & Sschting is described from Ukrainian Artemisia - Festuca steppes near the Black Sea. It grows on twigs of small shrubs of Halocnemum strobilaceum and Limonium sp.on salty soils, and is characterued by greenish grey areoles or squamules with punctiform to confluent soralia and zeorine apothecia with a conspicuous white pruina.

The objective of the CELLION project is radiation research at low doses. The main cell responses to low dose irradiation are bystander effects, genomic instability and adaptive responses. In order to study these effects it is convenient to make the cells addressable in space and time through locking the cell position. A new alternative dish has been developed for irradiation procedures at the Lund

Popular Abstract in Swedish Under de senaste åren har nödvändigheten att ta hänsyn till utsatta grupper i den svenska befolkningen och deras varierande behov lyfts fram i rapporter och utredningar om utformningen av vård och rehabilitering av äldre. En sådan utsatt grupp är äldre teckenspråkliga döva. Svårigheten att kommunicera, i kombination med åldersrelaterade sjukdomar, funktionsbegränsningarVery little is known about the consequences of aging and the wellbeing of deaf sign language users. This thesis contributes to filling this knowledge gap. The overarching aim was to gain further understanding and to increase the knowledge about quality of life, in terms of subjective wellbeing and health, activity and social contacts, among older deaf sign language users. After having established

2-Bromoethyl glycosides can easily and in high yields be transformed into sulfones by treatment with a suitable thiol followed by oxidation with mCPBA. The observation that the so formed sulfones were cleaved by treatment with NaOMe/MeOH was used to design a new safety catch linker for synthesis of glycoconjugates on solid support. (C) 2005 Elsevier Ltd. All rights reserved.

This study established the reliability of a novel upper-limb trajectory-tracking task for assessment of perceptual motor control in hemiparetic adults. Eleven persons with chronic poststroke hemiparesis (mean 58.6 months) and eleven nondisabled control subjects performed an elbow flexion-extension task against a low-resistance isotonic load at three speeds: 25degrees/s, 45degrees/s, and 65degrees/

The effects of small roundabouts on emissions and fuel consumption were evaluated using the “car-following” method in a before/after study. The results showed that at a roundabout replacing a signalised junction, CO emissions decreased by 29%, NOx emissions by 21%, and fuel consumption by 28%. At roundabouts, replacing yield regulated junctions, CO emissions increased on average by 4%, NOx emissio

Src homology 2 (SH2) domains recognize phosphotyrosine (pY)-containing sequences and thereby mediate their association to ligands. Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase, in which mutations cause a hereditary immunodeficiency disease, X-linked agammaglobulinemia (XLA). Mutations have been found in all Btk domains, including SH2, We have analyzed the structural and

Recension av Sofie Lene Bak, Jødeaktionen oktober 1943. Forestillinger i offentlighed og forskning