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Background: Parkinson’s disease (PD) is a neurodegenerative disorder associated with substantial costs that escalate as the disease progresses. Previous research has explored the relationship between disease progression, motor symptoms, and the economic burden of PD. However, there is a lack of studies focusing on the relationship between costs and non-motor symptoms (NMS). Objective: To examine t
Monolayer molybdenum ditelluride (MoTe2) attracted intensive scientific interest due to the small energy difference between its semiconducting (1H) and semimetallic (1T’) phases. Understanding MoTe2 polymorphism phenomena and developing pathways to induce reversible phase transformations is of great scientific and practical importance to develop semiconductor-semimetal phase change devices. In thi
How actors relate to the future has long been considered important in research on the governance of transformations towards sustainability. Recent contributions have explored the politics at play in the ‘making’ of futures and the forming of collective expectations. Building on the concept of socio-material incumbency and integrating academic discussions which appreciate the politics of future-mak
The German transportation sector's negative contribution to climate change amongst broader social, environmental, and economic problems is applying evermore pressure to the prevailing automobility regime to bring about its transformation. However, the vision of this transition, referred to as the Verkehrswende or Mobilitätswende, is highly contested, with varying conceptions of different actors ab
Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more
The family Eulophidae is a highly diverse monophyletic taxon recognizable chiefly by reduction in features of the antennae and legs, including having at most ten flagellomeres and four tarsomeres, and a reduced protibial spur. Eulophidae exhibit a very wide diversity of host relationships. Some are phytophagous, but most are idiobiont or koinobiont parasitoids of arthropods and even nematodes. The
Microplastics (MPs) in biosolids used as soil amendments are of growing concern. The purpose of this study was to improve the characterization of MPs in complex biosolid matrices by optimizing sample preparation for morphological and chemical analyses with different spectroscopic techniques. We compared extraction procedures involving Fenton oxidation (F), Fenton plus sodium dodecyl sulfate (SDS),
High-dimensional systems are an important frontier for photonic quantum correlation experiments. These correlation tests commonly prescribe measurements with many possible outcomes but they are often implemented through many individual binary-outcome measurements that use only a single-detector. Here, we discuss how this binarization procedure for multioutcome measurements can open a loophole, unl
In this work we tailor the response of trusses loaded beyond their yield limit. The truss structures are modeled using finite strain theory and rate-independent elasto-plasticity. We design trusses with a tailored mechanical response that is between “elastic” and “elastic-ideal-plastic” subject to the volume constraint. The design updates are generated by the gradient-based Method of Moving Asympt
INTRODUCTION: Hospital-acquired bloodstream infections (HA-BSIs) are severe and require antibiotic therapy. In non-complicated BSIs, shortened therapy reduces side effects without compromising efficacy. The impact of shortened antibiotic therapy in HA-BSI critically ill patients without indication of prolonged therapy requires further evaluation. METHODS: Using the international prospective EUROBA
Background: Acute appendicitis is one of the most common causes of acute abdominal pain. Differences in the management of this large group of patients has important consequences for the patients and the healthcare system. Controversies regarding the understanding of the natural course of the disease, the utility of new diagnostic methods, and alternative treatments have lead to large variations in
Compared to lake area and water level, lake storage capacity more intuitively reflects regional climate changes. In this study, we first derived lakebed elevation profiles for individual ICESat-2 tracks based on the underwater stratification of laser photons, then integrating all valid elevation tracks within the water body to interpolate the bathymetry. On this basis, we calculated the capacity a
Purpose: To compare the performance of targeted temperature management (TTM) at 33 °C using intravascular (IC) vs. surface-cooling (SFC) devices after out-of-hospital cardiac arrest (OHCA). Methods: A post hoc analysis including OHCA patients randomized to hypothermia in the TTM2-trial (NCT02908308) comparing hypothermia with normothermia. The main outcome was cooling performance, defined as the p
This review summarises some of the key features of interstitial lung diseases (ILDs) from a translational science point of view and brings insights into potential therapeutic options. Genetic predisposition and environmental factors like smoking, pollution and infections significantly impact the onset, progression and treatment response in ILDs, highlighting the need for personalised management. F
A large data set of new and previously published measurements of δ13C values derived from tooth enamel (n = 223, of which 93 are new) are compiled to explore patterns of foraging area preferences of Late Cretaceous mosasaurid squamates over evolutionary time scales (~93–66 Ma). Our results indicate that small-bodied halisaurines are restricted to a relatively nearshore range, overlapping the lower
English is spoken in a multitude of accents all over the world. But these accents are not neutral. They are a source of stereotypes. For example, people who speak with a Birmingham accent are considered less intelligent and less suitable as a university lecturer than people speaking with a standard British accent. This thesis investigates the factors that influence how English children develop theEnglish is spoken in a multitude of accents all over the world. But these accents are not neutral. They are a source of stereotypes. For example, people who speak with a Birmingham accent are considered less intelligent and less suitable as a university lecturer than people speaking with a standard British accent. This thesis investigates the factors that influence how English children develop the
This study explores the designs and dynamics of past, present, and potential mediation and negotiation efforts to stop the Russian invasion of Ukraine. Applying insights from mediation and negotiation literature, the article explores three questions relating to negotiating peace in Ukraine: who is best positioned to negotiate or mediate such a process (who should be presented at the table), when s
Through biosilicification, organisms incorporate dissolved silica (dSi) and deposit it as biogenic silica (bSi), driving the silicon (Si) cycle in aquatic systems. While Si accumulation in marine picocyanobacteria has been recently observed, its mechanisms and ecological implications remain unclear. This study investigates biosilicification in marine and brackish picocyanobacteria of the Synechoco
