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Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in hu-mans. It has previously been demonstrated that amiodarone and its metabolite (desethylamioda-rone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) and II (CII) of the elec-tron transport system in various animal tissues and cell types. The present study, performed in human peripheral blo
Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak’s seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative rol
The Apolipoprotein E4 (ApoE4) genotype is the most influential risk factor for sporadic Alzheimer's disease. It appears to be associated with retarded endosome-to-autophagosome trafficking. The amyloid precursor protein (APP) and the heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) are both processed in endosomes, and mutually regulated by the APP degradation products and the releas
Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate
Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in genetically at-risk children. Study Design: Children prospectively followed in the multinational T
Background: Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. Objective: To assess the safety and efficacy of CA for atrial arrhythmias in patients with ARVC. Methods: In th
Background: Previous studies have demonstrated a high prevalence of biochemical vitamin B12 deficiency in infants in Norway. Increased total homocysteine (tHcy) is the most important marker of B12 deficiency in infants. There is a need to evaluate its clinical relevance. Aims: To investigate the prevalence of hyperhomocysteinemia (S-tHcy > 8 μmol/L) suggestive of suboptimal B12 status and the prev
Barnobesitas är sedan flera år ett ökat hälsoproblem bland barn. Obesitas vid 4 års ålder ger en kraftigt ökad risk för obesitas senare i livet. Att förebygga uppkomst och utveckling av obesitas är en långsiktig investering för framtiden. Idag finns ingen evidensbaserad metod för vägledning inom barnhälsovården för att främja hälsosamma levnadsvanor och förebygga obesitas hos förskolebarn. Det övePrevention of childhood obesity with its effects on children’s mental and physical health and well-being is an international public health priority and is suggested to be effective when started early. As Child Health Services lack an evidence-based model, there is the need for development of a low-intensive health promotion model that is feasible and cost-effective in preventing obesity in prescho
Pneumonia is a global cause of mortality, and this provides a strong incentive to improve the mechanistic understanding of innate immune responses in the lungs. Here, we characterized the involvement of the cytokine interleukin (IL)-26 in bacterial lung infection. We observed markedly increased concentrations of IL-26 in lower airway samples from patients with bacterial pneumonia and these correla
Combined heat and power (CHP) production in combination with a district heating (DH) grid gives an energy-efficient use of wood fuels. The heat demand in the DH grid will, however, decline in the coming decades, and operators are seeking additional heat sinks. In this case study, the integration of a pyrolysis unit into an existing CHP plant was investigated as a possible solution. The retrofitted
Hippocampal atrophy is endemic in ‘normal aging’ but it is unclear what factors drive age-related changes in medial temporal lobe (MTL) structural measures. We investigated cross-sectional (n = 191) and longitudinal (n = 164) MTL atrophy patterns in cognitively normal older adults from ADNI-GO/2 with no to low cerebral β-amyloid and assessed whether white matter hyperintensities (WMHs) and cerebro
Treatment of bladder cancer has seen few advancements in recent decades until the introduction of checkpoint inhibitors during the last few years. Bladder cancer diagnostics have been similarly impaired and the likely advent of novel treatments in the neoadjuvant setting will require new diagnostic tools in the preoperative setting in muscleinvasive bladder cancer.This thesis evaluates three diagn
The confidentiality and integrity algorithms in cellular networks protect the transmission of user and signaling data over the air between users and the network, e.g., the base stations. There are three standardised cryptographic suites for confidentiality and integrity protection in 4G, which are based on the AES, SNOW 3G, and ZUC primitives, respectively. These primitives are used for providing
In this paper, channel measurement campaigns at center frequency of 72 GHz with 2 GHz bandwidth conducted by Huawei company are introduced. The transmitter and receiver make use of similar horn antennas which are rotated step by step in the directional domains to capture the frequency spectra of spatial channels in line-of-sight and non-line-of-sight scenarios of indoor environments. The data is a
In this paper, a recently conducted measurement campaign for high-speed-train (HST) channels is introduced, where the downlink signals of an in-service Universal Mobile Terrestrial System (UMTS) deployed along an HST railway between Beijing and Shanghai were acquired. The channel impulse responses (CIRs) are extracted from the data received in the common pilot channels (CPICHs). Within 1318 km, 14
In this paper, a novel fingerprint-based localization technique is proposed, which is applicable for positioning user equipments (UEs) in cellular communication networks such as the long-term-evolution (LTE) system. This technique utilizes a unique mapping between the characteristics of a radio channel formulated as a fingerprint vector and a geographical location. A feature-extraction algorithm i
In this paper, a measurement campaign for massive multiple-input multiple-output (MIMO) channel characterization in both line-of-sight (LoS) and non-LoS outdoor environments is introduced. The measurements are conducted at the center frequency of 15 GHz with a bandwidth of 4 GHz. A virtual 40× 40 planar antenna array formed by stepping a vertically-polarized bi-conical omni-directional antenna (OD
