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Stratigraphic boundaries are ideally defined by distinct lithological, geochemical, and palaeobiological signatures, to which a chronological framework can be applied. We present a range of observations that illustrate how the Holocene-Anthropocene transition meets these criteria in its expression in sediments from remote arctic and alpine lakes, removed from direct, catchment-scale, anthropogenic
We report on multiblock copolymers consisting of highly sulfonated hydrophilic poly(arylene sulfone) (SPAS) blocks combined with hydrophobic poly(arylene ether sulfone) (PAES) blocks. Dithiol-terminated precursor blocks of sulfonated poly(arylene thioether sulfone) (SPATS) were first prepared via polycondensations involving a novel tetrasulfonated dichlorotetraphenyldisulfone monomer, followed by
Prostate-specific antigen (PSA) testing has limited accuracy for the early detection of prostate cancer (PCa).
Many ICU-patients have memory-gaps which may affect their recovery. A tool in the recovery can be an ICU-diary to explain and clarify thoughts and events from the ICU-period. There are different standards for the content in the ICU-diary. The aim of this study was to identify the preferred content and usefulness of an ICU-diary as described by ICU-patients. METHOD: A descriptive, exploratory co
Classification of the open abdomen (OA) status is essential for clinical studies on the subject and may help to improve OA therapy. This is a validity and reliability analysis of the OA classification proposed by the World Society of the Abdominal Compartment Syndrome in 2013.
The aim of the study was to determine and compare the degree of swelling and the swelling kinetics of poly(ethylene oxide) (PEO) hydrophilic matrix tablets without any additives for matrixes with different molecular weight polydispersities. A wide range of "mixed" polydisperse PEO tablets were obtained by mixing two PEO batches with average molecular weights of 10(5) and 2 x 10(6), respectively. T
This paper studies the pricing of IPOs in a tractable model in which an investment bank faces some investors with superior information. We show how this can lead to underpricing and, based on our model, we make a number of empirical predictions.
Specific absorbed fractions (SAFs) have been calculated as a function of the content in the urinary bladder in order to allow more realistic calculations of the absorbed dose to the bladder wall. The SAFs were calculated using the urinary bladder anatomy from the ICRP male and female adult reference computational phantoms. The urinary bladder and its content were approximated by a sphere with a wa
Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dr
Polycomb Repressive Complex 2 (PRC2) plays a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is targeted to specific genomic loci within HSPCs remains unknown. Here we use shRNA-mediated knockdown to survey the function
The heterodinuclear complexes [FeZn(L)(CH3CO2)(2)](+) (L = ICIMP or IPCPMP) are structural models for the dinuclear active sites of plant purple acid phosphatases They can be systematically synthesized from mononuclear iron complexes and enhance the rate of transesterification of 2-hydroxypropyl p-nitrophenyl phosphate, an assay for the catalytic hydrolysis performed by purple acid phosphatases (C
The charge carrier dynamics of a new polymer-fullerene blend are examined on the femtosecond to the millisecond time scale. The full time range is globally fitted using a chemical reaction rate model that includes all key processes, charge generation, energy transfer, charge separation, and recombination, over the full 12 orders of magnitude in time and a factor of 33 in light intensity. Particula
In response to climate change, China's power industry is undertaking the task of reducing carbon emissions. Renewable energy generation has become an important option. For the government and state grid companies, it is important to know the maximum possible capacities of renewable energy generation from its different sources in order to plan the construction of the power grid in the future. In thi
We calculate the unpolarized transverse momentum dependent fragmentation function at next-to-next-to-leading order, evaluating separately the transverse momentum dependent (TMD) soft factor and the TMD collinear correlator. For the first time, the cancellation of spurious rapidity divergences in a properly defined individual TMD beyond the first nontrivial order is shown. This represents a strong
AZD0837 is a novel oral anticoagulant investigated in clinical studies for stroke prevention in patients with atrial fibrillation (AF). It is bioconverted to its active form, AR-H067637, a potent, specific and reversible thrombin inhibitor.
Production of chiral amines using omega-transaminases has been thoroughly studied in recent years. Immobilized w-transaminases, however, have been used on relatively few occasions despite potential benefits such as reuse of enzyme and ease of product purification. In this study principally different methods including surface immobilization, entrapment and sweep flocculation using titanium oxide. C
We show that strongly interacting multicomponent gases in one dimension realize an effective spin chain, offering an alternative simple scenario for the study of one-dimensional (1D) quantum magnetism in cold gases in the absence of an optical lattice. The spin-chain model allows for an intuitive understanding of recent experiments and for a simple calculation of relevant observables. We analyze t
Streptococcal toxic shock syndrome (STSS) is associated with a high mortality rate. The M1 serotype of Streptococcus pyogenes is most frequently associated with STSS. Herein, we examined the role of Ras signaling in M1 protein-induced lung injury. Male C57BL/6 mice received the Ras inhibitor (farnesylthiosalicylic acid, FTS) prior to M1 protein challenge. Bronchoalveolar fluid and lung tissue were
The European REACH legislation accepts the use of non-testing methods, such as QSARs, to inform chemical risk assessment. In this paper, we aim to initiate a discussion on the characterization of predictive uncertainty from QSAR regressions. For the purpose of decision making, we discuss applications from the perspective of applying QSARs to support probabilistic risk assessment. Predictive uncert
