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BACKGROUND: IdeS, a proteinase from Streptococcus pyogenes, cleaves immunoglobulin (Ig)G antibodies with a unique degree of specificity. Pathogenic IgG antibodies constitute an important clinical problem contributing to the pathogenesis of a number of autoimmune conditions and acute transplant rejection. To be able to effectively remove such antibodies is therefore an important clinical challenge.
The author extends the ideas of Bardyszewski and Hedin (1987) to treat EXAFS. He summarises the theory, adds new viewpoints and extends the theory.
Kulturartikel om den europeiska filmens katastrofala ekonomi och misslyckade försök att konkurrera mot amerikansk filmindustri med konstfilmsproduktion.
We have a very limited knowledge about how the confinement mechanism works in processes like $\epea\epe\ra\epq\epqa\ggn\ldots\ggn$, when there are identical colour charges. In this case the partons can be colour connected by a string or a cluster chain in several different ways. We do not know if in such a situation Nature chooses a particular configuration at random, or if some configuration is d
This short report draws attention to an interesting kind of configuration in the lexicon that seems to have escaped theoretical or systematic descriptive attention. These configurations, which we dub SEMPLATES, consist of an abstract structure or template, which is recurrently instantiated in a number of lexical sets, typically of different form classes. A number of examples from different languag
Major intrinsic proteins (MIPs) also called aquaporins form pores in membranes to facilitate the permeation of water and certain small polar solutes across membranes. MIPs are present in virtually every organism but are uniquely abundant in land plants. To elucidate the evolution and function of MIPs in terrestrial plants, the MIPs encoded in the genome of the spikemoss Selaginella moellendorffii
The ever-evolving understanding of the neuronal systems involved in Parkinson's disease together with the recent advances in recombinant viral vector technology has led to the development of several gene therapy applications that are now entering into clinical testing phase. To date, four fundamentally different approaches have been pursued utilizing recombinant adeno-associated virus and lentivir
In this paper we investigate a generalization of Gallager's (1963) low-density (LD) parity-check codes, where as component codes single error correcting Hamming codes are used instead of single error detecting parity-check codes. It is proved that there exist such generalized low-density (GLD) codes for which the minimum distance is growing linearly with the block length, and a lower bound of the
EWSR1 is involved in chimeric proteins which play crucial roles in the development of a variety of bone and soft tissue tumors. Many of the chimeric genes involving EWSR1 have been extensively studied, whereas less is known about the wild-type (wt) gene and its regulation. As the expression of the chimeric gene is driven by the EWSR1 promoter, it is of importance to study the mechanisms regulating
Peak matched multiple windows (PM MW) were used to estimate the spectrogram of the electroencephalogram (EEG). The authors focussed on the ability to estimate frequency changes, and especially resolving close peaks. A peak of known frequency was evoked in the EEG in a predetermined time interval. The PM MW spectrogram was compared to the commonly used single Hanning window and to weighted overlapp
