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The retail industry is transforming at an unprecedented speed and scale with the advent of omnichannel strategies, thus leading to growing concerns about its environmental impact. The purpose of this paper is to identify the requirements that affect the possibilities of obtaining environmentally sustainable omnichannels and the strategies to be used by retailers and logistics service providers (LS
Groundwater, as a vital water resource in arid and semi-arid regions, plays a crucial role in sustaining human livelihoods, agriculture, and industry. Over recent decades, these areas have witnessed rapid groundwater depletion, raising concerns about resource sustainability. This research provides a comprehensive analysis of the factors contributing to the decline in groundwater levels (GWL) withi
Background and aims: Targeted omics techniques can be used to identify systemic blood biomarkers associated with coronary artery disease (CAD) and cardiovascular disease (CVD) events. Our aim was to study associations between plasma protein, metabolite biomarkers and subclinical CAD in a low and a high CVD risk population. Methods: The Swedish CArdioPulmonary bioImage Study (SCAPIS) was used for i
Melanoma brain metastases (MBM) exhibit extensive intertumor and intratumor heterogeneity (ITH), driven by a complex tumor microenvironment. The aim of this study was to perform a detailed analysis of individual MBM patient tumors using a multiomics approach, integrating spatial transcriptomics with multi-region bulk exome, proteome, and transcriptome profiling for a small group of four patient sa
OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of immunosuppressants with or without corticosteroids compared to corticosteroid monotherapy for the treatment of IgG4-related disease in people 18 years or older.
A pervasive dilemma in brain-wide association studies1 (BWAS) is whether to prioritize functional magnetic resonance imaging (fMRI) scan time or sample size. We derive a theoretical model showing that individual-level phenotypic prediction accuracy increases with sample size and total scan duration (sample size × scan time per participant). The model explains empirical prediction accuracies well a
Van der Waals heterostructures have become a rapidly growing field in condensed matter research, offering a platform to engineer novel quantum systems by stacking different two-dimensional (2D) materials. A diverse range of material combinations, including hexagonal boron nitride, transition metal dichalcogenides and graphene, with electronic properties spanning from insulating to semiconducting,
OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the comparative effectiveness of monoclonal antibodies (mAbs) for preventing respiratory syncytial virus (RSV) infection in children, and to evaluate the relative rankings for benefits and harms of mAbs for preventing RSV in children.
Perturbed secretion of insulin and other pancreatic islet hormones is the main cause of type 2 diabetes (T2D). The islets harbor five cell types that are potentially altered differently by T2D. Whole-islet transcriptomics and single-cell RNA-sequencing (scRNAseq) studies have revealed differentially expressed genes without reaching consensus. Here, we demonstrate that further insights into T2D dis
HfO2, one of the most common materials in resistive switching devices, can stabilize in a ferroelectric orthorhombic phase, enabling two nonvolatile polarization states via oxygen displacement in the unit cell. Under certain conditions, ferroelectric and resistive switching can coexist, independently addressable, within one device. This study employs operando spectroscopic analysis to elucidate th
Polyploidization is an important driver of evolution and diversification in flowering plants. Here, we assess how repeated polyploidization may have shaped diversification of floral morphology in Lithophragma bolanderi (Saxifragaceae). This species comprises multiple cytotypes and varies geographically in its interactions with specialized pollinating moths in the genus Greya (Prodoxidae). Past stu
This chapter explores Afghanistan's relationship with international law. Post-2001 statebuilding efforts in Afghanistan involved a strong commitment to reintegrating the Afghan state into the international legal system. However, a significant gap existed between formal commitments and on-the-ground realities. This chapter examines Afghanistan's relationship with international law by focusing on fo
It is a continued open question how there can be an azimuthal anisotropy of high particles quantified by a sizable in p+Pb collisions when, at the same time, the nuclear modification factor is consistent with unity. We address this puzzle within the framework of the jet quenching model \textsc{Jewel}. In the absence of reliable medium models for small collision systems we use the number of scat
In this paper, a new Monte Carlo Glauber model is developed for pA collisions. It uses the hadronic cross sections calculated within the KMR model as implemented in the SHRiMPS minimum bias module of the SHERPA event generator. These cross sections are obtained as functions of impact parameter and, therefore, are ready for use in a Glauber model without additional assumptions regarding their impac
The onset of jet quenching, i.e. the suppression of high transverse momentum particles and jets, is an important question in the context of understanding the onset of collective behaviour and small collision systems. We investigate a minimal scenario where a hard parton experiences a single soft re-scattering that leaves the kinematics unmodified, but the colour exchange leads to a loss of colour
Intelligence scholars have described the contemporary availability ofOpen-Source Intelligence (OSINT) and the entrance of civil society actorsinto the field of intelligence as a “democratization of intelligence”, therebyportraying a fundamentally positive and inclusive enterprise. Assessingthe implications of the recent explosion of OSINT groups and activists fortraditional state intelligence acto
Background We investigate whether, in Swedish national registers, social and psychiatric outcomes for six major psychiatric and substance disorders - drug use disorder (DUD), alcohol use disorder (AUD), major depression (MD), bipolar disorder (BD), anxiety disorder (AD), and schizophrenia (SZ) - reflect the primary genetic risk for each disorder and the level of genetic heterogeneity. Methods We u
The European Green Deal (EGD) aims for agriculture to contribute positively to climate change mitigation and nature preservation while meeting growing societal needs for food, energy, and biomaterials. Delivering comprehensive policy action efficiently requires decision-support tools to assess the outcomes of interventions across multiple, and potentially conflicting, goals. By means of agent-base
