Filetype
Twenty years ago, Hales and Barker along with their co-workers published some of their pioneering papers proposing the 'thrifty phenotype hypothesis' in Diabetologia (4;35:595-601 and 3;36:62-67). Their postulate that fetal programming could represent an important player in the origin of type 2 diabetes, the metabolic syndrome and cardiovascular disease (CVD) was met with great scepticism. More re
Growing evidence for declines in wild bees calls for the development and implementation of effective mitigation measures. Enhancing floral resources is a widely accepted measure for promoting bees in agricultural landscapes, but effectiveness varies considerably between landscapes and regions. We hypothesize that this variation is mainly driven by a combination of the direct effects of measures on
BACKGROUND: With regard to contact allergy, the dose of a sensitizer per unit skin area is an important factor for both sensitization and elicitation, and therefore a known amount/volume of test preparation should be applied at patch testing. OBJECTIVES: To compare three different techniques for the application of aqueous solutions to Finn Chambers, in order to determine the precision and accuracy
Intravenous fluid treatment of hypovolaemia in states of increased capillary permeability, e.g. sepsis, is often accompanied by adverse oedema formation. A challenge is therefore to achieve and maintain normovolaemia using as little plasma volume substitution as possible to minimise interstitial oedema. In the present study, we evaluated the importance of infusion rate for the plasma volume expand
Objectives: Parkinson's disease (PD) has traditionally been associated with weight loss. However, recent studies have not found any evidence of underweight in PD. Nevertheless, few studies have addressed nutritional status changes over time in relation to other clinical PD features. Here, we explore changes in nutritional status and motor and non-motor PD features (including dopaminergic drug ther
This study shows how cod subpopulations may have been eradicated as a consequence of the use of imperfect models for assessing stock assessment, depleting what was formerly a productive sea. The Kattegat and Oresund (North Sea) were chosen as study objects due to the combination of different exploitation patterns and the possible existence of separate stock units. The scenario was further elaborat
Modeling Parkinson's disease remains a major challenge for preclinical researchers, as existing models fail to reliably recapitulate all of the classic features of the disease, namely, the progressive emergence of a bradykinetic motor syndrome with underlying nigrostriatal alpha-synuclein protein accumulation and nigrostriatal neurodegeneration. One limitation of the existing models is that they a
Abstract The Abbé flap is a procedure where the volume of the upper lip is increased at the expense of the lower lip. This study reviewed the Abbé flaps done at Skåne University Hospital during the years 1991-2006 and identified 14 patients. Data was collected from medical records. Eleven patients were deemed fit for interviews and were called to the hospital by standard mail. Six patients respond
The surface-selective surface deposition of anionic hydrophilic silica particles from aqueous polymer-surfactant formulations was investigated by in-situ null-ellipsometry. The formulations, with or without silica particles, contained anionic sodium dodecylsulfate (SDS) and a cationic polymer, cationic hydroxyethyl cellulose (cat-HEC) or a copolymer of acrylamide and methacrylamidopropyl trimethyl
A palynologial study of the Ordovician-Silurian boundary (Katian–Rhuddanian) succession in the Röstånga-1 drillcore, southern Sweden, has been performed. The lithology is dominated by mudstone and graptolitic shale, with subordinate limestone, formed in the deeper marine halo of southern Baltica. The palynological assemblages are dominated by marine microfossils, mainly chitinozoans and acritarchs
This paper reports for the first time the application of sol-gel microarrays for immobilizing nonsoluble small chemicals (Bisphenol-A; BPA). Also, known problems of sol-gel adhesion to conventional microtiter well plate substrates are circumvented by anchoring the sol-gel microspots to a porous silion surface so-called, PS-SG chips. We confirmed low molecular weight chemical immobilization inside
Skeletal muscle is a key tissue site of insulin resistance in type 2 diabetes. Human myotubes are primary skeletal muscle cells displaying both morphological and biochemical characteristics of mature skeletal muscle and the diabetic phenotype is conserved in myotubes derived from subjects with type 2 diabetes. Several abnormalities have been identified in skeletal muscle from type 2 diabetic subje
Aquaglyceroporins are transmembrane proteins belonging to the family of aquaporins, which facilitate the passage of specific uncharged solutes across membranes of cells. The yeast aquaglyceroporin Fps1 is important for osmoadaptation by regulating intracellular glycerol levels during changes in external osmolarity. Upon high osmolarity conditions, yeast accumulates glycerol by increased production
Objective: Health and lifestyle factors are associated with variations in serum testosterone levels in ageing men. However, it remains unclear how age-related changes in testosterone may be attenuated by lifestyle modifications. The objective was to investigate the longitudinal relationships between changes in health and lifestyle factors with changes in hormones of the reproductive endocrine axis
When used in combination with raster scanning, small-angle X-ray scattering (SAXS) has proven to be a valuable imaging technique of the nanoscale, for example of bone, teeth and brain matter. Although two-dimensional projection imaging has been used to characterize various materials successfully, its three-dimensional extension, SAXS computed tomography, poses substantial challenges, which have ye
Cell abundances and distributions of Alexandrium catenella resting cysts in recent sediments were studied along time at two locations in the Chilean Inland Sea exposed to different oceanographic conditions: Low Bay, which is much more open to the ocean than the more interior and protected Ovalada Island. The bloom began in interior areas but maximum cyst concentrations were recorded in locations m
We construct 4-dimensional Riemannian Lie groups carrying left-invariant conformal foliations with minimal leaves of codimension 2. We show that these foliations are holomorphic with respect to an (integrable) Hermitian structure which is not Kähler. We then prove that the Riemannian Lie groups constructed are not Einstein manifolds. This answers an important open question in the theory of complex
A major goal in evolutionary biology is to determine how phenotypic variation arises and is maintained in natural populations. Recent studies examining the morphological, physiological and behavioural differences among discrete colour morphotypes (morphs) have revealed several mechanisms that maintain discrete variation within populations, including frequency-dependence, density-dependence and cor
Abstract Alpha-particle emitters, such as astatine-211 ((211)At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 ((177)Lu), have a longer path length and are considered better for small, established tumors. A combination of such radionuclides may be successful in regimens of radioimm
