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Background and objectives: Maximal safe resection is the cornerstone of diffuse low-grade glioma (dLGG) management, although epidemiological data are limited. We aim to explore surgical selection, techniques, and outcomes in a population-based cohort. Materials and methods: This study utilized a multi-center case series (9 out of 10 neurosurgical departments in Norway and Sweden) of all adults (≥1
Study objectives: Narcolepsy type 1 (NT1) is a chronic sleep disorder characterized by loss of hypocretin-producing neurons. Increased NT1 incidence was observed in Sweden following mass-vaccination with Pandemrix®. Genetic association to HLA DQB1*06:02 implies an autoimmune origin, but target autoantigen remains unknown. Candidate autoantigens for NT1 have previously been identified in solid-phas
Police work may include performing repeated tasks under the influence of psychological stress, which can affect perceptual, cognitive and motor performance. However, it is largely unknown how repeatedly performing stressful tasks physically affect police officers in terms of heart rate and pupil diameter properties. Psychological stress is commonly assessed by monitoring the changes in these bioma
BACKGROUND: Pancreatic adenocarcinoma located in the pancreatic body might require a portomesenteric venous resection (PVR), but data regarding surgical risks after distal pancreatectomy (DP) with PVR are sparse. Insight into additional surgical risks of DP-PVR could support preoperative counseling and intraoperative decision making. This study aimed to provide insight into the surgical outcome of
Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of
Background: Cervical cancer is preventable through screening and vaccination against high-risk human papillomavirus (hr-HPV). For a screening program to be successful it is vital that the clinical management and follow-up regime of patients with abnormal screening results is well developed and that the attendance rate for follow-up is high. The aim of the study was to analyze how effective conizat
Corrosion of embedded steel reinforcement is the prime influencing factor that deteriorates the structural performance and reduces the serviceability of reinforced concrete (RC) structures, especially during earthquakes. In structural elements, RC columns play a vital role in transferring the superstructure's load to the substructure. The deterioration of RC columns can affect the structures' over
Importance: Clinical studies confirm that obesity is a risk factor for recurrence in postmenopausal women with hormone receptor-positive (HR+) breast cancer. Evidence suggests that women with obesity do not obtain similar protection from aromatase inhibitors as women with healthy weight. Objective: To examine the associations of body mass index (BMI) with recurrence. Design, Setting, and Participa
The aim of this thesis is to contribute to the understanding of everyday leisure travel for social and recreational trip purposes by describing and problematising car use for such trips. Leisure trips are a significant contributor to greenhouse gas emissions and reductions are needed to mitigate climate change. Technical solutions, such as electric vehicles, contribute but research has demonstrate
Tree recruitment forms an essential process in forest growth models as it determines the amount and composition of the next generation of trees and, hence, the provision of forest ecosystem services over long time spans. With global change and the hereby associated changes in environmental conditions and forest management adaptations, the common static tree recruitment modelling approaches have be
PURPOSE: There is uncertainty whether ER-low tumors with a 1-10% immunohistochemical staining of nuclei represent a distinct molecular biological entity of BC, posing significant challenges for their clinical management and developing novel therapies. We aimed to elucidate ER-low tumor biology.EXPERIMENTAL DESIGN: We analyzed primary tumors included in a Swedish population-based SCAN-B BC cohort,
Aerosols from volcanic eruptions impact our climate by influencing the Earth's radiative balance. The degree of their climate impact is determined by the location and injection altitude of the volcanic SO2. To investigate the importance of utilizing correct injection altitudes, we ran climate simulations of the June 2009 Sarychev eruptions with three SO2 datasets in the Community Earth System Mode
Om sakerna på ditt skrivbord inte har tillverkats genom skärande bearbetning, så har definitivt verktyget som användes för att tillverka dem gjort det. Skärande bearbetning har en stor men ganska dold inverkan på ditt liv. Då den enda skärande bearbetning du kanske har upplevt är att göra en ljusstake i träslöjden i grundskolan. Svarvningen och fräsningen i denna avhandling rör ej ljusstakar i träIn an era where 3D printing and AI are at the forefront, turning, milling, and metal cutting might seem like niche research topics from the past. But metal cutting is all around you. If what you have lying on your desk was not machined, then the tools used to create it certainly were. Even 3D-printed or additively manufactured parts must be machined if a good surface quality is needed for an indus
Background: An accurate medication list at hospital admission is essential for the evaluation and further treatment of patients. The objective of this study was to describe the frequency, type and predictors of errors in medication history, and to evaluate the extent to which standard care corrects these errors.Methods: A descriptive study was carried out in two medical wards in a Swedish hospital
Popular Abstract in SwedishEn av de viktigaste forskningsfrågorna inom matematikutbildning handlar om förståelse. Det huvudsakliga syftet med den här avhandlingen har varit att nå insikt i olika förståelseformer i skolmatematik och former av lärandeidentiteter i två lärandemiljöer. Avhandlingens specifika fokus var flexibla sätt att urskilja delar och avgränsa helheter och undersöka hur lärande inA central question in mathematics education research concerns understanding. The main objective of the present thesis has been to obtain insights into flexible modes of knowing in school mathematics in two school class contexts, and how these relate to modes of being a learner in these contexts, with specific focus on learners’ flexible ways of discerning parts and delimiting wholes, and how they
Background. Kidney involvement is common in anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) and the prognosis is determined by the severity of kidney damage. This study focused on long-term kidney outcomes, defining possible risk factors and comparing the performance of three different histological classifications to predict outcomes for patients with AAV. Methods. The dataset inclu
The 10E8 antibody targets a helical epitope in the membrane-proximal external region (MPER) and transmembrane domain (TMD) of the envelope glycoprotein (Env) subunit gp41 and is among the broadest known neutralizing antibodies against HIV-1. Accordingly, this antibody and its mechanism of action valuably inform the design of effective vaccines and immunotherapies. 10E8 exhibits unusual adaptations
Introduction: The alarming global increase in lifestyle-related disorders such as obesity and type 2 diabetes mellitus (T2DM) has increased during the last several decades. Poor dietary choices significantly contribute to this increase and prevention measures are urgently needed. Dietary intake of bioactive compounds found in foods are linked to a decrease likelihood of these disorders. For t
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this ser
Objective: To compare the reproductive outcome after early miscarriage between women managed expectantly and those treated with vaginal misoprostol. Methods: This study was a planned secondary analysis of data collected prospectively in a randomized controlled trial comparing expectant management with vaginal misoprostol treatment (single dose of 800 µg) in women with early embryonic or anembryoni
