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Numerous Neoproterozoic mafic dykes, referred to as the Dashigou swarm, are identified in the central and southeastern parts of the North China craton (NCC). They are 305-010 degrees trending dykes, with widths of similar to 10-100 m and exposed lengths of several to >10 km. Precise U-Pb isotope dilution thermal ionization mass spectrometry (ID-TIMS) measurements on baddeleyite grains separated fr

Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation

Bone marrow-derived mesenchymal stromal cells (MSCs) target glioma extensions and micro-satellites efficiently when implanted intratumorally. Here, we report that intratumoral implantation of MSCs and peripheral immunotherapy with interferon-gamma (IFNγ) producing tumor cells improve the survival of glioma-bearing rats (54% cure rate) compared to MSC alone (0% cure rate) or immunotherapy alone (21

Nanowires are commonly used as tools for interfacing living cells, acting as biomolecule-delivery vectors or electrodes. It is generally assumed that the small size of the nanowires ensures a minimal cellular perturbation, yet the effects of nanowires on cell migration and proliferation remain largely unknown. Fibroblast behaviour on vertical nanowire arrays is investigated, and it is shown that c

We report the association of an inherited variant located upstream of the poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) gene (rs2249844), with survival in 11 BioGenoMEL melanoma cohorts. The gene encodes a protein involved in a number of cellular processes including single-strand DNA repair. Survival analysis was conducted for each cohort using proportional hazards regression adjusting f

The RNA-binding motif protein 3 (RBM3) was initially discovered as a putative cancer biomarker based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). We previously reported an association between high expression of RBM3 and prolonged survival in breast and epithelial ovarian cancer (EOC). Because the function of RBM3 has not been fully elucidated, the aim of

Colorectal cancer is the third most common cancer type in the western world. in search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(

We have investigated the effects of short-term neoadjuvant and long-term androgen deprivation therapies (ADTs) on beta-microseminoprotein (MSMB) and cysteine-rich secretory protein-3 (CRISP3) expression in prostate cancer patients. We also studied if MSMB expression was related to genotype and epigenetic silencing. Using an Affymetrix cDNA microarray analysis, we investigated the expression of MSM

Popular Abstract in Swedish Syftet med denna avhandling är att studera den vanligaste behandlingskomplikationen vid blödarsjuka, antikroppsbildning, samt att studera sambandet mellan genen som orsakar sjukdom och det protein som denna gen kodar för. Det övergripande syftet är att forskningsresultaten ska kunna användas för att förbättra vården för familjer med blödarsjuka (hemofili). Resultaten vThe general objective of the research underlying this dissertation was to conduct clinical and basic scientific studies to further elucidate the hemophilia and the coagulation process, with the goal of improving the care of families with these disorders. More specific aims were to evaluate epidemiological, genetic, clinical, and biochemical aspects of the development of inhibitors (antibodies) aga

Prostate cancer (PCa) is one of the most common cancers in men and is the second leading cause of cancer-related deaths in the USA. In the United States, it is the second most frequently diagnosed cancer after skin cancer, and in Europe it is number one. According to the American Cancer Society, approximately 221,000 men in the United States would be diagnosed with PCa during 2015, and approximate

Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. Here, we repor

Under de senaste åren har antalet vårdnadstvister som avgjorts i domstol ökat markant i Sverige. Samtidigt har Sverige blivit ett mer mångkulturellt samhälle med en ökad arbetskraftsinvandring och kontinuerliga flykting- strömmar. I dagsläget har fler familjer än någonsin anknytning till utlandet vilket förstärker vissa problem inom familjerätten. Flera barn blir varje år olovligen bortförda ifrånIn recent years, the number of custody disputes settled in court has increased significantly in Sweden. This as a consequence of that Sweden has become a more multicultural society with increased labor migration and continuous refugee flows. Currently, more families than ever have links with foreign countries, which reinforces certain problems within family law. Several children are unlawfully abd

7,3 miljoner flickor under 18 år föder varje år. En av tre flickor i länder med låg- eller medelinkomst kommer att gifta sig före 18 års ålder. Detta är en kränkning mot flickor och deras mänskliga rättigheter. United Nations Population Fund, UNFPA arbetar med att stärka kvinnors och unga människors möjligheter att leva ett hälsosammare och ett mer produktivt liv. Med detta i åtanke är syftet att

Synergieffekter med ett avrinningsområdesperspektiv vid utformning av klimatstrategier Klimatförändringen ställer krav på naturmarken vi har i Sverige i form av utsläppsminskning, kolinlagring och klimatanpassning. Då avrinningen kan öka eller minska beroende på markanvändning är det viktigt med ett avrinningsområdets perspektiv vid utformningen av klimatstrategier. Det är särskilt angeläget då öClimate change places pressure on rural land in terms of carbon sequestration, biomass for substitution and adaptation of crops. Land use can both positively and negatively influence the runoff regime, therefor a catchment perspective is important when developing climate strategies. This is also important with respect to flood-risk that will increase with climate change. Here I investigate if ther

Recent public opinion research and elite deliberation has established a particular interest in galvanizing an EU army to better enforce a sense of integration, stability and strengthin the Union. This article proposes an alternative mechanism, privileging Richard Rosecrance’s concept of the ‘virtual state’ as anequally important and worthyfactor contributing to all those aspects. The fourdefining

Denna studie fokuserar på Säkerhetspolisens hotbildsframställningar av den våldsfrämjande islamistiska extremismen och studien syftar till att undersöka hur hotbildsframställningarna förändrats efter terrorattentatet på Drottninggatan i Stockholm den 7 april 2017. Studien är en abduktiv och teorikonsumerande fallstudie som använder sig av en kombination av säkerhetiseringsteorin och gestaltningste

Sverige har en lång tradition av industriell verksamhet vilket har lett till att områden har förorenats. Jönköpings län har bland annat präglats av kvarnverksamhet där betning av utsäde bedrivits. Betning utfördes för att skydda sädeskornets ytskikt mot svampangrepp när det såddes ut på åkrarna. Betningsmedlet som användes var Panogen som är en metylkvicksilverförening. Användningen av detta betni

Workplace social media monitoring has become increasingly prevalent, raising critical concerns about privacy and fairness in employee-employer relationships. This thesis investigated the associations between the Big Five personality traits and employee perceptions of social media monitoring in the workplace. Using a quantitative research design, the study examined how openness, conscientiousness,

Barsebäcks kärnkraftverk driftsattes 1975 och den första reaktorn togs ur drift 1999 och den andra 2005. Nedmontering och rivning av kärnkraftverket har inletts och processen beräknas vara klar på 2030-talet. Syftet med detta examensarbete är att kartlägga eventuell radioaktiv kontamination i området runt Barsebäcksverket. Mitt mål är att ta fram en metod för att särskilja bakgrundsstrålning från Background and aim: The Barsebäck nuclear power plant (NPP) units ceased operations in 1999 and 2005. Now the NPP is in the phase of decommissioning, which is a complicated process that will take many years to complete. Radiological characterization of the surrounding area is a part of the decommissioning process. The aim of this thesis was to identify and quantify residual anthropogenic radioacti