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There has been great interest in the rationales for transformative innovation policies (TIP), including those following a mission-oriented logic. However, few studies have investigated how public administration can effectively implement TIP. To study this, we first identify from existing literature four TIP governance tasks (creating legitimacy and leadership, coordination across levels/instrument

Integration is described as fundamental for immigrants in order for them to establish a normal life in a new and unknown country. Mass migration is a current globally discussed problem, described as a social problem due to increased crime, usually blamed on failed attempts at integration. This study discusses the Swedish Fathima project organized by Save the Children’s Youth Association. The Fathi

It is now well established that there is a reciprocal relationship between the content of literature and societal norms. Within feminist criticism, this has been highlighted as problematic, as women are often not portrayed fairly. In this essay, I will examine the relationship between literature and society by comparing the 19th-century Medieval novels Ivanhoe (1819) by Sir Walter Scott and The Wh

BackgroundTo enable immunotherapy for ovarian cancers, precision targets for immune priming as well as patient stratification approaches are required. The tumor microenvironment in particularly the rare subtypes of low-grade serous, mucinous, clear cell and endometrioid ovarian cancer, remains poorly characterized, and these tumors have been largely ignored in the immuno-oncology setting.MethodsWe

Innate-like T cells (ILTCs) link innate immune responses with adaptive immune functions. This group includes invariant natural killer T (iNKT) cells, mucosa-associated invariant T (MAIT) cells, and γδ T cells. ILTCs detect transformed or stressed cells via non-classical antigen presentation pathways. For example, iNKT cells recognize CD1d-presented glycolipids, MAIT cells respond to MR1-presented

This research outlines the evolution of the manufacturing and industrial export structure of countries, Estonia, Lithuania, and Latvia since 1992 within the framework of Economic Complexity and the Product Space. The research reveals a relatively low level of specialization in the countries’ export structures and identifies a dual structure within the economy due to the foreign ownership of firms.

Somatic hypermutation and isotype switch recombination occur in germinal center B cells, are linked to transcription, and are similarly affected by deficiency in MutS homologue (MSH)2. Class-switch recombination is abrogated by disruption of genes encoding components of the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs))/Ku complex and likely involves nonhomologous end joining (NHEJ

BACKGROUND: Transcatheter aortic valve implantation is an effective treatment for patients with aortic stenosis; however, complications related to paravalvular leakage (PVL) persist, including increased risk of mortality, cardiovascular mortality, and rehospitalisation. AIMS: We sought to evaluate the clinical outcomes and valve performance at 1 year in patients with severe aortic stenosis treated

This chapter examines the evolution of social class segregation in the city of Landskrona during the twentieth century. The city’s population was initially spatially mixed with regards to social class but became more segregated with industrialization. The study reveals that the segregation of higher white-collar workers increased drastically from 1940 to 1960, with a concentration of this group in

We present the first results of an experiment which is aimed at ultimately producing recommendations for analysing archaeologic ceramics specimens using hand held XRF analysis devices. In the experiment we study the effects of different measurement durations, different number of measured points, and three different types of surface treatments (breakage, polished, grounded) when analysing ceramics

Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carbonates. Structurally, PON1 is a six-bladed β-propeller with a flexible loop (residues 70-81) covering the active site. This loop contains a functionally critical Tyr at position 71. We have performed detailed experimental and computational a

Background: Affectivity has been suggested as a complex adaptive meta-system composed of positive affect and negative affect, two independent but interrelated markers of well-being, that can be represented as four distinct affective profiles: self-fulfilling (high positive affect/low negative affect), high affective (high positive affect/high negative affect), low affective (low positive affect/lo

Background: During the last years, the affective profiles model has been applied to study individual differences among Spanish children in psychological characteristics, such as optimism and pessimism. This research has replicated past studies from adult and adolescent Swedish populations by identifying four profiles using clustering methods on self-reports of children’s experience of positive (PA

HIV-2, compared to HIV-1, elicits potent and broadly neutralizing antibodies, and uses a broad range of co-receptors. However, both sensitivity to neutralization and breadth of co-receptor use varies between HIV-2 isolates, and the molecular background is still not fully understood. Thus, in the current study, we have deciphered relationships between HIV-2 neutralization sensitivity, co-receptor u

This chapter covers prosodic features of languages across Southwestern, Central, and Northern Asia. One representative language from each of the four main language families is passed in review, Turkish (Turkic), Mongolian (Mongolic), Persian (Indo-European), and Georgian (Kartvelian). Owing to a lack of descriptive coverage of the prosody of languages in Central Asia, no comprehensive surveys are