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Objective: To assessmyoepithelium with p63 in fresh breast cancer (BC)tissue samples collected in RNA later for further analysis with NextGeneration Sequencing (NGS) technique. For a better understanding ofthe NGS bulk-analysis, a central part of the sample in RNA-later isformalin-fixed paraffin-embedded to score relative cellularity in % onhematoxylin-eosin (HE) staining (% of invasive cancer, ca

Objective: Estrogen receptor (ER) positive breast cancer (BC) can havean insidious course with disease-relapse decades after primary surgery.New analysis performed on archived formalin-fixed paraffin-embedded(FFPE) tissue are important for disease-management in late BC-relapseand an important tool in BC-research. However, although loss of immunoreactivityin tissue slides after sectioning has been

With the present demand on fast and inexpensive aerosol source apportionment methods, the Aethalometer model was evaluated for a full seasonal cycle (June 2014–June 2015) at a rural atmospheric measurement station in southern Sweden by using radiocarbon and levoglucosan measurements. By utilizing differences in absorption of UV and IR, the Aethalometer model apportions carbon mass into wood burnin

Although recommended by the Kidney Disease Improving Global Outcomes, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPICR) creatinine equation was not targeted to estimate glomerular filtration rate (eGFR) among older adults. The Berlin Initiative Study (BIS1CR) equation was specifically developed in older adults, and the Lund-Malmö revised (LMRCR) and the Full Age Spectrum (FASCR) eq

Recension av Sam Popowich bok Confronting the Democratic Discourse of Librarianship

Iron centeredN-heterocyclic carbene (Fe-NHC) complexes have shown long-lived excited states with charge transfer character useful for light harvesting applications. Understanding the nature of the metal-ligand bond is of fundamental importance to rationally tailor the properties of transition metal complexes. The high-energy-resolution fluorescence detected X-ray absorption near edge structure (HE

A new generation of octahedral iron(ii)-N-heterocyclic carbene (NHC) complexes, employing different tridentate C^N^C ligands, has been designed and synthesized as earth-abundant photosensitizers for dye sensitized solar cells (DSSCs) and related solar energy conversion applications. This work introduces a linearly aligned push-pull design principle that reaches from the ligand having nitrogen-base

Spatially coupled serially concatenated codes (SC-SCCs) are a class of spatially coupled turbo-like codes, which have a close-to-capacity performance and low error floor. In this paper, we perform a comprehensive design space exploration, revealing different aspects of SC-SCCs and discussing various design trade-offs. In particular, we investigate the impact of coupling memory, block length, decod

X-ray propagation-based imaging techniques are well established at synchrotron radiation and laboratory sources. However, most reconstruction algorithms for such image modalities, also known as phase-retrieval algorithms, have been developed specifically for one instrument by and for experts, making the development and diffusion of such techniques difficult. Here, PyPhase, a free and open-source p

Background: Colorectal cancer screening programmes and uptake vary substantially across Europe. We aimed to compare changes over time in colorectal cancer incidence, mortality, and stage distribution in relation to colorectal cancer screening implementation in European countries. Methods: Data from nearly 3·1 million patients with colorectal cancer diagnosed from 2000 onwards (up to 2016 for most

The semiconductor industry is pivotal to Europe's economy, especially within the industrial and automotive sectors. However, Europe faces a significant shortfall in chip design capabilities, marked by a severe skilled labor shortage and lagging contributions in the design value chain segment. This paper explores the role of European universities and academic initiatives in enhancing chip design ed

AIMS/HYPOTHESIS: The incidence of type 1 diabetes increased during the pandemic in various countries. SARS-CoV-2 infections may trigger the development of type 1 diabetes, but the evidence is inconclusive. This study aimed to assess trends in type 1 diabetes incidence between 2007 and 2023, and to quantify the association between SARS-CoV-2 infections and the risk for developing type 1 diabetes.ME

Eye movements do more than gather visual input – they actively contribute to the formation and retrieval of relational memories by linking information across space and time. During retrieval, gaze patterns often reflect memory reactivation well before an explicit response is made, a phenomenon known as the relational eye-movement effect. While this effect appears closely associated with hippocampa

Reconfigurable intelligent surface (RIS) can manipulate the electromagnetic (EM) waves in wireless channels and thus is promising for the sixth generation wireless communication systems. However, there exists little research on RIS channel measurements, which are important for the communication system design. In this paper, channel measurements are carried out in anechoic chamber, outdoor, and ind

Background: The European Union (EU) AI Act (AIA) aims to facilitate trustworthy Artificial Intelligence (AI) systems, especially for safety-critical use cases. Compliance with this new regulation entails a multitude of legal, technical, and organizational challenges for the providers of affected systems.Objective: This regulatory compliance engineering research aims for an empirical exploration an

Eye movements originally made during memory formation are often spontaneously reproduced during retrieval, even in the absence of visual input, directing gaze back to the locations where goal-relevant episodic information was previously encountered. This behavior, known as gaze reinstatement, is thought to support the reactivation of episodic content associated with those locations (e.g., Johansso