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Leflunomide is a low molecular weight immunosuppressive drug which inhibits the enzymes dehydroorotate dehydrogenase and protein tyrosine kinase, both of which are important components in the immune response. As the mechanisms of action of leflunomide and tacrolimus are different, we postulated an additive or synergistic effect of the two drugs and investigated the effects of leflunomide alone, or

Inherent difficulties in growing protein crystals are major concerns within structural biology and particularly in structural proteomics. Here, we describe a novel approach of engineering target proteins by surface mutagenesis to increase the odds of crystallizing the molecules. To this end, we have exploited our recent triad-hypothesis using proteins with crystallographically defined beta-structu

When designing a new basic course in statistics for students in Environmental Engineering at Lund University, our aim was that assessment should be an integral part of the course. We found that there were several factors to be considered, such as how the assessment should be in line with the goals of the course and with the teaching method. One piece of the assessment is a major project and we dis

Ad utrumque (paratus), latin for “prepared for both”, is the motto of Lund University. When the University was founded in 1666 its primary mission was to secure the southern provinces of Scania to the Swedish king. Scania had previously belonged to Denmark, but the peace settlement of 1658 made them part of Sweden. The seal of the university also shows the carolingian lion reading a book while hol

Welding aerosols have been sampled in different size fractions using a moving stage cascade impactor. Sampling has been done for different welding methods and for varying welding parameters. The elemental composition of the different size fractions have been determined by Proton Induced X-ray Emission, PIXE, combined with a nuclear method for fluorine analysis. Results show maximum mass of most el

Popular Abstract in Swedish Uppsättningen av gener i DNA, genomet, kan betraktas som drivande för konstruktionen av varje levande varelse, medan motsvarande proteiner, proteomet, är materiellt ansvariga för de flesta biologiska processer. Kort sagt, gener bestämmer vad celler ”ska kunna göra” medan proteiner definierar vad varje cell "gör" ur en funktionell synvinkel. Aktiviteten hos dessa molekylAmongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. Alas, since state-of-the-art technologies cannot meet the complexity of upper eukaryotic proteomes, a complete resolution of clinical samples is still una

Uppsatsriktlinjer Historiska institutionen Riktlinjer för uppsatsarbete på magisternivå - 2 - Innehåll ALLMÄNNA RIKTLINJER .................................................................................................. 3 UPPSATSKURSENS FUNKTION OCH MÅL ................................................................................... 3 ATT SKRIVA OCH VENTILERA EN MAGISTERUPPSATS ..............

https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISS40/20191/UppsatsriktlinjerMagister.pdf - 2026-05-24

This study aims to analyze the effects of competition on quality, efficiency, produced volume and gaming the system of specialized health care in Sweden, after implementation of the Freedom of Choice Act (LOV, Lagen om Vårdval). This is done by using data for specialized ophthalmology, which is a patient-elective diagnostic category. The motive behind the law, which established free entry for priv

In the last decades, scholars, managers and consultants have shown increased interest in identifying the characteristics of high-performance organizations. Searching for ways to improve organizational performance and respond to a growing demand for quality products and services in a rapidly changing environment, this subject is of special interest of managers in both public and private organizatio

The study investigates how the early nineteenth century invention of comparative-historical linguistics affected European ethnohistoric thought, and how this process altered ethnohistorical research on the early, pre-Christian history of the Nordic region. The case study of the Nordic region (Denmark, Iceland, Norway, Sweden, Finland and Estonia) includes the discipline histories of Finno-Ugric st

We present how dramatically the nonequilibrium nature of an oppsitely charged polyelectrolyte/surfactant mixture can affect the interfacial properties. We show for the first time that the cliff edge peak in the surface tension of the poly(diallydimethylammonium chloride)/sodium dodecyl surfate system is produced as a direct result of depletion of surface-active material from the bulk solution due

The dynamics of planetesimals and planetary cores may be strongly influenced by density perturbations driven by magneto-rotational turbulence in their natal protoplanetary gas disks. Using the local shearing box approximation, we perform numerical simulations of planetesimals moving as massless particles in a turbulent, magnetized, unstratified gas disk. Our fiducial disk model shows turbulent acc

The Swedish Pompeii Project started in 2000 as a fieldwork initiated from the Swedish Institute in Rome. The aim was to record and analyze a full Pompeian city-block, Insula V 1. This paper presents the initial results of one of the actions in the context of this project. In October 2011, two houses were acquired using 3D scanning and 3d-from-photos techniques, and the data was processed to obtain