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A fedbatch process shows exponential growth under ideal conditions. To obtain good substrate concentration control it is necessary that the regulator can track an exponentially growing feed demand, and standard PI-control has to be supplemented with an estimated basic dosage to get reasonable control. However, an exponentially growing concentration error is impossible to avoid. An I-term could be

It is a well-established practice in European cities to use large-scale projects for the purpose of geographical branding. As a radical strategy, urban renewal projects are used for branding purposes. To communicate visions to internal and external stakeholders are essential to establish and legitimize processes of change and large investments and costs related to the project. The aim of the stud

The bacterial spore, the hardiest known life form, can survive in a metabolically dormant state for many years and can withstand high temperatures, radiation, and toxic chemicals. The molecular basis of spore dormancy and resistance is not understood, but the physical state of water in the different spore compartments is thought to play a key role. To characterize this water in situ, we recorded t

Highly efficient washing and extraction of microbeads to decomplex analytes ranging from small peptides to large viruses was realised in a microscaled continuous flow format. The bead washing principle reported herein is based on acoustophoresis, i.e. the primary acoustic radiation force in an ultrasonic standing wave and laminar flow properties are utilised to translate bioanalytes trapped on fun

Leflunomide is a low molecular weight immunosuppressive drug which inhibits the enzymes dehydroorotate dehydrogenase and protein tyrosine kinase, both of which are important components in the immune response. As the mechanisms of action of leflunomide and tacrolimus are different, we postulated an additive or synergistic effect of the two drugs and investigated the effects of leflunomide alone, or

Inherent difficulties in growing protein crystals are major concerns within structural biology and particularly in structural proteomics. Here, we describe a novel approach of engineering target proteins by surface mutagenesis to increase the odds of crystallizing the molecules. To this end, we have exploited our recent triad-hypothesis using proteins with crystallographically defined beta-structu

When designing a new basic course in statistics for students in Environmental Engineering at Lund University, our aim was that assessment should be an integral part of the course. We found that there were several factors to be considered, such as how the assessment should be in line with the goals of the course and with the teaching method. One piece of the assessment is a major project and we dis

Ad utrumque (paratus), latin for “prepared for both”, is the motto of Lund University. When the University was founded in 1666 its primary mission was to secure the southern provinces of Scania to the Swedish king. Scania had previously belonged to Denmark, but the peace settlement of 1658 made them part of Sweden. The seal of the university also shows the carolingian lion reading a book while hol

Welding aerosols have been sampled in different size fractions using a moving stage cascade impactor. Sampling has been done for different welding methods and for varying welding parameters. The elemental composition of the different size fractions have been determined by Proton Induced X-ray Emission, PIXE, combined with a nuclear method for fluorine analysis. Results show maximum mass of most el

Popular Abstract in Swedish Uppsättningen av gener i DNA, genomet, kan betraktas som drivande för konstruktionen av varje levande varelse, medan motsvarande proteiner, proteomet, är materiellt ansvariga för de flesta biologiska processer. Kort sagt, gener bestämmer vad celler ”ska kunna göra” medan proteiner definierar vad varje cell "gör" ur en funktionell synvinkel. Aktiviteten hos dessa molekylAmongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. Alas, since state-of-the-art technologies cannot meet the complexity of upper eukaryotic proteomes, a complete resolution of clinical samples is still una