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Antibodies targeting Ab42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Ab42. Each antibody in the panel is rationally designed to target a specific linear epitope, with the selected epitopes scanning the Ab42 sequence. By screen

Objective: To evaluate the test-retest reliability and variability of the Participation domain of the Stroke Impact Scale (SIS Participation) in persons with stroke as it is widely used to assess perceived participation in rehabilitation after stroke. Design: A test-retest design. Subjects: Forty-five persons (mean age 65 years) with mild to moderate disability at least 6 months post-stroke. Metho

Purpose: A hybrid planar-SPECT/CT method for tumor dosimetry in 177Lu-DOTATATE therapy, applicable to datasets consisting of multiple conjugate-view images and one SPECT/CT, is developed and evaluated. Methods: The imaging protocol includes conjugate-view imaging at 1, 24, 96, and 168 h post infusion (p.i.) and a SPECT/CT acquisition 24 h p.i. The dosimetry method uses the planar images to estimat

Under 2018 stormade det kring Svenska Akademien. I samband med detta trädde kungen plötsligt fram och menade sig ha befogenhet att ändra Akademiens stadgar. Detta innebär ett exempellöst utflöde av makt från kungen som inte har förekommit tidigare under 1974 års regeringsform och efter Torekovskompromissen. I denna text ska jag försöka presentera och diskutera de olika argument som har förts fram

From the point of view of semiotics, the essential contribution of John Deely consists in having made us all aware of the richness of the Scholastic heritage, and to have explained it to us latter-day semioticians. Even for those, who, like the present author, think that semiotics was alive and well between the dawn of the Latin Age, and the rediscovery of Scholastic realism by Peirce, the notions

Objective: Vascular endothelial growth factor D (VEGF-D) has important functions in lymphangiogenesis and angiogenesis. High plasma levels of VEGF-D have been associated with incidence of heart failure. The association of VEGF-D with atrial fibrillation (AF) and stroke is unclear and we hypothesised that VEGF-D could also be associated with incidence of AF and ischaemic stroke. Methods: VEGF-D was

BACKGROUND: As the patents of originator biologics are expiring, biosimilar versions are becoming available for the treatment of inflammatory bowel disease (IBD). However, published switch studies of the first infliximab biosimilar, CT-P13, have delivered ambiguous results that could be interpreted as showing a trend towards inferior effectiveness in Crohn's disease (CD) compared with ulcerative c

Evidence-based practice (EBP) has been launched, spread, and established in social work in Sweden in the last decade. Today, impact studies and ‘what works’ are the recommended approaches, and medical ways to understand and examine social problems thus are prioritised over the broad social science perspectives on which social work rests. This development has culminated in an institutionalised syst

Chromosomal aberrations (CAs) in human peripheral blood lymphocytes (PBL) measured with the conventional cytogenetic assay have been used for human biomonitoring of genotoxic exposure for decades. CA frequency in peripheral blood is a marker of cancer susceptibility. Previous studies have shown associations between genetic variants in metabolic pathway, DNA repair and major mitotic checkpoint gene

Explaining macroevolution from microevolution is a key issue in contemporary evolutionary theory. A recurrent macroevolutionary pattern is that some niche-related traits consistently evolve slower than others, so called niche conservatism. Despite a growing amount of data, the underlying evolutionary processes are not fully understood. I here analyse adaptive radiations in an individual-based eco-

Hip fractures in elderly carry a high mortality. Our objective was to test the hypothesis that plasma lactate concentration at hospital admission can be used to identify patients with a high risk for poor outcome. Hip fracture patients admitted to a university hospital in Sweden from January 2011 to August 2014 in whom a venous lactate was obtained at admission were included in this prospective ob

Purpose: To examine the outcome of the use of donor sclera as spacer material in complicated cases of strabismus surgery. Methods: A retrospective cohort study on patients with complicated thyroid-associated ophthalmopathy (TAO) (n = 42) or congenital strabismus (n = 75). Patients underwent strabismus surgery during 1994–2014. The surgical results were evaluated in terms of the reduction in the an

The European Court of Human Rights (ECtHR) has reiterated that states have discretion regarding what means to use to fulfil their positive obligations under the European Convention on Human Rights (echr). Given the "wide range of possible measures" that could be taken to ensure compliance with positive rights, these rights have a disjunctive structure since an omission has no definitive counterpar

In this paper, a mathematical model is presented, by which the cutting forces in a gear hobbing process and the wear behaviour of the hob's all cutting teeth are predicted. The load on each individual hob cutting tooth varies heavily in the gear hobbing process. To predict the cutting force, and subsequently the tool wear, a detailed determination of the chip geometry is needed. The undeformed chi

This paper presents an emergent process model of conflict enactment in new venture teams. The analysis is based on the inductive study of conflict process in three new venture teams over six months, leveraging a unique combination of interviews, video recorded observations and analysis of online chat conversations among team members. The analysis advances team conflict research by offering a novel

The concern of this paper is with the mediatisation of tourism cities through fast circulating narratives on digital platforms in an era characterised as post-truth involving the spread of fake news and disinformation. Hence far, there is scarce knowledge on how misleading information and false rumours concerning terrorism affect the image of tourism cities. In addition, extant research studies pr

With increasing demands on the industry for resource efficiency, processes are often built or retrofitted withrecycle streams in order to decrease energy and raw material demands. However, this also increases thecomplexity of the process as a whole and may bring unexpected effects. In this contribution, such a case,consisting of a two-stage evaporator system, fed with the product stream of an upst